ID CYPB_ORPSP STANDARD; PRT; 203 AA. AC Q01490; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Peptidyl-prolyl cis-trans isomerase B precursor (EC 5.2.1.8) (PPIase) DE (Rotamase) (Cyclophilin B). GN CYPB. OS Orpinomyces sp. (strain PC-2). OC Eukaryota; Fungi; Chytridiomycota; Neocallimasticales; OC Neocallimasticaceae; Orpinomyces. OX NCBI_TaxID=50059; RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 23-52. RX MEDLINE=95223986; PubMed=7708690; RA Chen H., Li X.-L., Ljungdahl L.G.; RT "A cyclophilin from the polycentric anaerobic rumen fungus Orpinomyces RT sp. strain PC-2 is highly homologous to vertebrate cyclophilin B."; RL Proc. Natl. Acad. Sci. U.S.A. 92:2587-2591(1995). CC -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes CC the cis-trans isomerization of proline imidic peptide bonds in CC oligopeptides. CC -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline CC (omega=0). CC -!- ENZYME REGULATION: Inhibited by cyclosporin A (CSA). CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity). CC -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U17900; AAD04195.1; -. DR HSSP; P23284; 1CYN. DR InterPro; IPR002130; CSA_PPIase. DR Pfam; PF00160; pro_isomerase; 1. DR PRINTS; PR00153; CSAPPISMRASE. DR PROSITE; PS00170; CSA_PPIASE_1; 1. DR PROSITE; PS50072; CSA_PPIASE_2; 1. KW Cyclosporin; Isomerase; Rotamase; Signal; Endoplasmic reticulum. FT SIGNAL 1 22 FT CHAIN 23 203 Peptidyl-prolyl cis-trans isomerase B. FT BINDING 147 147 CYCLOSPORIN A (CSA) (POTENTIAL). FT SITE 200 203 Prevent secretion from ER (By FT similarity). SQ SEQUENCE 203 AA; 21969 MW; A5748C94305B8BE0 CRC64; MNFSIKSVIF LAIVALATLV SASTNPKVTN KVYFDIKQGD KDLGRIVLGL YGEVVPKTVE NFRALATGEK GYGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFA DENFKLRHTG PGILSMANAG RDTNGSQFFI TTVTTSWLDG RHVVFGKVIE GMDVVTAIET TKTLPGDRPA TPVIIADCGE LPVSNNNDAK AEL //