ID Q01490 PRELIMINARY; PRT; 203 AA. AC Q01490; DT 01-NOV-1998 (TrEMBLrel. 08, Created) DT 01-NOV-1998 (TrEMBLrel. 08, Last sequence update) DT 01-DEC-2001 (TrEMBLrel. 19, Last annotation update) DE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B PRECURSOR (EC 5.2.1.8) (PPIASE) DE (CYCLOPHILIN B) (ROTAMASE). GN CYPB. OS Orpinomyces sp. PC-2. OC Eukaryota; Fungi; Chytridiomycota; Neocallimasticales; OC Neocallimasticaceae; Orpinomyces. OX NCBI_TaxID=50059; RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 23-52. RX MEDLINE=95223986; PubMed=7708690; RA Chen H., Li X.-L., Ljungdahl L.G.; RT "A cyclophilin from the polycentric anaerobic rumen fungus Orpinomyces RT sp. strain PC-2 is highly homologous to vertebrate cyclophilin B."; RL Proc. Natl. Acad. Sci. U.S.A. 92:2587-2591(1995). CC -!- FUNCTION: PPIASES ACCELERATE THE FOLDING OF PROTEINS. CC -!- CATALYTIC ACTIVITY: CIS-TRANS ISOMERIZATION OF PROLINE IMIDIC CC PEPTIDE BONDS IN OLIGOPEPTIDES. CC -!- ENZYME REGULATION: CYCLOSPORIN A (CSA) INHIBITS CYPB. CC -!- SUBCELLULAR LOCATION: ENDOPLASMIC RETICULUM LUMEN (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U17900; AAD04195.1; -. DR HSSP; P23284; 1CYN. DR InterPro; IPR002130; CSA_PPIase. DR Pfam; PF00160; pro_isomerase; 1. DR PRINTS; PR00153; CSAPPISMRASE. DR PROSITE; PS00170; CSA_PPIASE_1; 1. DR PROSITE; PS50072; CSA_PPIASE_2; 1. KW Isomerase; Rotamase; Signal; Cyclosporin; Endoplasmic reticulum. FT SIGNAL 1 22 FT CHAIN 23 203 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B. FT BINDING 147 147 CSA (POTENTIAL). FT SITE 200 203 PREVENT SECRETION FROM ER FT (BY SIMILARITY). SQ SEQUENCE 203 AA; 21969 MW; A5748C94305B8BE0 CRC64; MNFSIKSVIF LAIVALATLV SASTNPKVTN KVYFDIKQGD KDLGRIVLGL YGEVVPKTVE NFRALATGEK GYGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFA DENFKLRHTG PGILSMANAG RDTNGSQFFI TTVTTSWLDG RHVVFGKVIE GMDVVTAIET TKTLPGDRPA TPVIIADCGE LPVSNNNDAK AEL //