ID POL2_BAYMG STANDARD; PRT; 890 AA. AC Q01365; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Genome polyprotein 2 [Contains: Helper component proteinase DE (EC 3.4.22.45) (HC-Pro); 70 kDa protein]. OS Barley yellow mosaic virus (German isolate) (BaYMV). OC Viruses; ssRNA positive-strand viruses, no DNA stage; Potyviridae; OC Bymovirus. OX NCBI_TaxID=31728; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91202139; PubMed=2016598; RA Davidson A.D., Proels M., Schell J., Steinbiss H.H.; RT "The nucleotide sequence of RNA 2 of barley yellow mosaic virus."; RL J. Gen. Virol. 72:989-993(1991). CC -!- CATALYTIC ACTIVITY: Hydrolyzes a Gly-|-Gly bond at its own C- CC terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the CC processing of the potyviral polyprotein. CC -!- SIMILARITY: HC PROTEINASE BELONGS TO PEPTIDASE FAMILY C6. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D01099; BAA00884.1; -. DR PIR; JQ1947; JQ1947. DR MEROPS; C06.002; -. DR InterPro; IPR001337; TMV_coat. DR Pfam; PF00721; TMV_coat; 1. KW Polyprotein; Hydrolase; Thiol protease. FT CHAIN 1 255 HEPLER COMPONENT PROTEINASE (POTENTIAL). FT CHAIN 256 890 70 kDa PROTEIN. FT ACT_SITE 143 143 POTENTIAL. FT ACT_SITE 215 215 POTENTIAL. FT SITE 255 256 CLEAVAGE (BY HC-PRO PROTEASE) FT (POTENTIAL). SQ SEQUENCE 890 AA; 98203 MW; 753AB79EABAD3640 CRC64; MSTSSSRLFF DCGSLDWPNK SLFGDPTTRD VMDEHISSTW NAVIRRHMLA PNADAETILG RDGLPSAQFD AYGAMLPSFI QALNAPTTRL RISAPLSTAE SILCADASHA PWLYMANSVC AYEATHLQPV QTFIAFNFAH GYCYLSLFIP LSFRITPENA RSFSRFLEQL PDILGAYPTL ASLYKTMLFA VRLFPEVLQA PIPIIAKRPG VLQFHVSDAR GLPPSWFPMK CGSVASFIAL ITNNLNSDLL NGIVGSNGDG EHYTNWNSGH NHWIVNRFIT VKDLHSSLKS ALEVDLDTEG GRNAVLDLLL DLGVTNLVRR EKRFPAYFQG AESVYLLLSC ERVGNELVAV QDALQEPLAN YTGKDLRALI INLGGLPSRH PEICYTRNIF ENDNHLVWNF EFYRIASITK NAQIDRDVLS SSMANLFSDF VSESSNGEYR VKEPRPVTQY RVEHDEPVAS GAPSAWWQVL VGITTAILGA IIFFLWRCFL RAKRVKFQAK DSFPWFTTSG DDDLPPPPGD SPSRPPGRSP DRVLPRTVVR DLSFNDDDDL HSVDLNEAGS RFGEVVSLIA RGNLRELAGA IPESLSNLTL LQTSASGSGF YTMVALYLAT LGDAITAFHE HNDASPATIQ SLRTLELQLE ARGLRFNEAG TPANLIQRGV KSSVGRALVR LTQSALLATG ENFRTRMAAT LERIAAERLN TLTAYDQRVI EMTTELLAAI KTALEVERSE LTPHLANAEA LLQVYNNLFS TDYASASLLA LRREMILRSA EGRVGEQPTS ASDAANEELV QRSMTKLDKE IELFQAQIDS QRRAVTITEA SNLRENILQP INTVANIAMA GAFLRGGARH RMPGIPDVAA PMSNPFRAFS GRGHSLTTTR GAGLFRRPRV //