ID   FCERB_HUMAN             Reviewed;         244 AA.
AC   Q01362; Q54A81;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   17-JUN-2020, entry version 167.
DE   RecName: Full=High affinity immunoglobulin epsilon receptor subunit beta;
DE            Short=FcERI;
DE   AltName: Full=Fc epsilon receptor I beta-chain;
DE   AltName: Full=IgE Fc receptor subunit beta;
DE   AltName: Full=Membrane-spanning 4-domains subfamily A member 2;
GN   Name=MS4A2; Synonyms=APY, FCER1B, IGER;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1535625;
RA   Kuester H., Zhang L., Brini A.T., Macglashan D.W., Kinet J.-P.;
RT   "The gene and cDNA for the human high affinity immunoglobulin E receptor
RT   beta chain and expression of the complete human receptor.";
RL   J. Biol. Chem. 267:12782-12787(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1386024; DOI=10.1016/0014-5793(92)80430-o;
RA   Maekawa K., Imagawa N., Tanaka Y., Harada S.;
RT   "Determination of the sequence coding for the beta subunit of the human
RT   high-affinity IgE receptor.";
RL   FEBS Lett. 302:161-165(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12697656; DOI=10.1093/intimm/dxg055;
RA   Akizawa Y., Nishiyama C., Hasegawa M., Maeda K., Nakahata T., Okumura K.,
RA   Ra C., Ogawa H.;
RT   "Regulation of human FcepsilonRI beta chain gene expression by Oct-1.";
RL   Int. Immunol. 15:549-556(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   VARIANT GLY-237, AND INVOLVEMENT IN ATOPIC ASTHMA SUSCEPTIBILITY.
RX   PubMed=8817330; DOI=10.1093/hmg/5.7.959;
RA   Hill M.R., Cookson W.O.;
RT   "A new variant of the beta subunit of the high-affinity receptor for
RT   immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of
RT   atopy and bronchial hyper-responsiveness.";
RL   Hum. Mol. Genet. 5:959-962(1996).
RN   [6]
RP   VARIANT GLY-237, AND INVOLVEMENT IN ATOPIC ASTHMA SUSCEPTIBILITY.
RX   PubMed=8842731; DOI=10.1093/hmg/5.8.1129;
RA   Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K.,
RA   Hopkin J.;
RT   "Association between atopic asthma and a coding variant of Fc-epsilon-RI-
RT   beta in a Japanese population.";
RL   Hum. Mol. Genet. 5:1129-1130(1996).
RN   [7]
RP   ERRATUM OF PUBMED:8842731.
RX   PubMed=8968765;
RA   Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K.,
RA   Hopkin J.;
RL   Hum. Mol. Genet. 5:2068-2068(1996).
CC   -!- FUNCTION: High affinity receptor that binds to the Fc region of
CC       immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens
CC       is required for the full mast cell response, including the release of
CC       preformed mediators (such as histamine) by degranulation and de novo
CC       production of lipid mediators and cytokines. Also mediates the
CC       secretion of important lymphokines. Binding of allergen to receptor-
CC       bound IgE leads to cell activation and the release of mediators
CC       responsible for the manifestations of allergy.
CC   -!- SUBUNIT: Tetramer of an alpha chain, a beta chain, and two disulfide
CC       linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN
CC       (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q01362; Q8N2M4: TMEM86A; NbExp=5; IntAct=EBI-13384102, EBI-12015604;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Found on the surface of mast cells and basophils.
CC   -!- PTM: Phosphorylated on tyrosine residues by LYN. {ECO:0000250}.
CC   -!- POLYMORPHISM: Variant Glu-237 has been found to be present in about
CC       5.3% of a 1004 individuals population sample in Australia
CC       (PubMed:8817330). {ECO:0000269|PubMed:8817330}.
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR   EMBL; D10583; BAA01440.1; -; mRNA.
DR   EMBL; M89796; AAA60269.1; -; Genomic_DNA.
DR   EMBL; AB080913; BAC66486.1; -; Genomic_DNA.
DR   EMBL; BC074800; AAH74800.1; -; mRNA.
DR   EMBL; BC074843; AAH74843.1; -; mRNA.
DR   CCDS; CCDS7980.1; -.
DR   PIR; A42806; A42806.
DR   RefSeq; NP_000130.1; NM_000139.4.
DR   RefSeq; XP_011543152.1; XM_011544850.2.
DR   SMR; Q01362; -.
DR   BioGRID; 108500; 4.
DR   CORUM; Q01362; -.
DR   IntAct; Q01362; 1.
DR   STRING; 9606.ENSP00000278888; -.
DR   DrugBank; DB00043; Omalizumab.
DR   TCDB; 1.A.37.3.2; the cd20 ca(2+) channel (cd20) family.
DR   iPTMnet; Q01362; -.
DR   PhosphoSitePlus; Q01362; -.
DR   BioMuta; MS4A2; -.
DR   DMDM; 232084; -.
DR   MassIVE; Q01362; -.
DR   PaxDb; Q01362; -.
DR   PeptideAtlas; Q01362; -.
DR   PRIDE; Q01362; -.
DR   ProteomicsDB; 57942; -.
DR   ABCD; Q01362; 2 sequenced antibodies.
DR   Antibodypedia; 27859; 72 antibodies.
DR   Ensembl; ENST00000278888; ENSP00000278888; ENSG00000149534.
DR   GeneID; 2206; -.
DR   KEGG; hsa:2206; -.
DR   UCSC; uc001nop.4; human.
DR   CTD; 2206; -.
DR   DisGeNET; 2206; -.
DR   EuPathDB; HostDB:ENSG00000149534.8; -.
DR   GeneCards; MS4A2; -.
DR   HGNC; HGNC:7316; MS4A2.
DR   HPA; ENSG00000149534; Tissue enriched (blood).
DR   MalaCards; MS4A2; -.
DR   MIM; 147138; gene.
DR   neXtProt; NX_Q01362; -.
DR   OpenTargets; ENSG00000149534; -.
DR   PharmGKB; PA31109; -.
DR   eggNOG; ENOG410J28C; Eukaryota.
DR   eggNOG; ENOG4111DU9; LUCA.
DR   GeneTree; ENSGT00940000161985; -.
DR   HOGENOM; CLU_093202_0_0_1; -.
DR   InParanoid; Q01362; -.
DR   KO; K08090; -.
DR   OMA; MACFSTE; -.
DR   OrthoDB; 1048914at2759; -.
DR   PhylomeDB; Q01362; -.
DR   TreeFam; TF335157; -.
DR   Reactome; R-HSA-2454202; Fc epsilon receptor (FCERI) signaling.
DR   Reactome; R-HSA-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR   Reactome; R-HSA-2871796; FCERI mediated MAPK activation.
DR   Reactome; R-HSA-2871809; FCERI mediated Ca+2 mobilization.
DR   Reactome; R-HSA-2871837; FCERI mediated NF-kB activation.
DR   SignaLink; Q01362; -.
DR   SIGNOR; Q01362; -.
DR   BioGRID-ORCS; 2206; 4 hits in 787 CRISPR screens.
DR   GeneWiki; MS4A2; -.
DR   GenomeRNAi; 2206; -.
DR   Pharos; Q01362; Tbio.
DR   PRO; PR:Q01362; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q01362; protein.
DR   Bgee; ENSG00000149534; Expressed in fundus of stomach and 99 other tissues.
DR   ExpressionAtlas; Q01362; baseline and differential.
DR   Genevisible; Q01362; HS.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0032998; C:Fc-epsilon receptor I complex; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0019863; F:IgE binding; IEA:UniProtKB-KW.
DR   GO; GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0006955; P:immune response; IMP:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   InterPro; IPR030420; MS4A2.
DR   PANTHER; PTHR23320; PTHR23320; 1.
DR   PANTHER; PTHR23320:SF66; PTHR23320:SF66; 1.
DR   Pfam; PF04103; CD20; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; IgE-binding protein; Membrane; Phosphoprotein;
KW   Polymorphism; Receptor; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..244
FT                   /note="High affinity immunoglobulin epsilon receptor
FT                   subunit beta"
FT                   /id="PRO_0000158629"
FT   TOPO_DOM        1..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..180
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         219
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P20490"
FT   MOD_RES         225
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P20490"
FT   MOD_RES         226
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P20490"
FT   MOD_RES         229
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P20490"
FT   VARIANT         143
FT                   /note="T -> M (in dbSNP:rs35033981)"
FT                   /id="VAR_053515"
FT   VARIANT         211
FT                   /note="N -> K (in dbSNP:rs535630)"
FT                   /id="VAR_053516"
FT   VARIANT         237
FT                   /note="E -> G (polymorphism; risk factor for atopic
FT                   dermatitis and asthma; dbSNP:rs569108)"
FT                   /evidence="ECO:0000269|PubMed:8817330,
FT                   ECO:0000269|PubMed:8842731"
FT                   /id="VAR_003965"
SQ   SEQUENCE   244 AA;  26534 MW;  CE523102D5F567AF CRC64;
     MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF
     LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY PFWGAIFFSI SGMLSIISER
     RNATYLVRGS LGANTASSIA GGTGITILII NLKKSLAYIH IHSCQKFFET KCFMASFSTE
     IVVMMLFLTI LGLGSAVSLT ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP
     PIDL
//