ID Q00I03_LEPAN Unreviewed; 115 AA. AC Q00I03; DT 14-NOV-2006, integrated into UniProtKB/TrEMBL. DT 14-NOV-2006, sequence version 1. DT 29-SEP-2021, entry version 51. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|RuleBase:RU003640}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003640}; OS Lepilemur ankaranensis (Ankarana sportive lemur) (Lepilemur septentrionalis OS ankaranensis). OG Mitochondrion {ECO:0000313|EMBL:ABG73826.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; OC Lepilemuridae; Lepilemur. OX NCBI_TaxID=342401 {ECO:0000313|EMBL:ABG73826.1}; RN [1] {ECO:0000313|EMBL:ABG73826.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DAR4.35 {ECO:0000313|EMBL:ABG73826.1}; RA Louis E.E. Jr, Engberg S.E., Lei R., Geng H., Sommer J.A., RA Randriamampionona R., Randriamanana J.C., Zaonarivelo J.R., RA Andriantompohavana R., Randria G., Prosper, Ramaromilanto B., RA Rakotoarisoa G., Rooney A., Brenneman R.A.; RT "Molecular and morphological analyses of the sportive lemurs (Family RT Megaladapidae: Genus Lepilemur) reveals 11 previously unrecognized RT species."; RL Spec. Publ. Mus. Tex. Tech. Univ. 49:1-47(2006). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity of complex I. CC {ECO:0000256|RuleBase:RU003640}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU003640}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003640}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ529627; ABG73826.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.58.1610; -; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR PANTHER; PTHR11058; PTHR11058; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003640}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640}; KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:ABG73826.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640}; KW Respiratory chain {ECO:0000256|RuleBase:RU003640}; KW Translocase {ECO:0000256|RuleBase:RU003640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003640}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003640}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640}; KW Ubiquinone {ECO:0000256|RuleBase:RU003640}. FT TRANSMEM 7..24 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" FT TRANSMEM 55..79 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" FT TRANSMEM 86..107 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" SQ SEQUENCE 115 AA; 13094 MW; C4EB968D96D9FA91 CRC64; MNLPLTITIN TLMVTILVMI AFWLPQLNVY TEKYNPYECG FDPMGSARLP FSMKFFLVAI TFLLFDLGIA LLLPLPWAIQ MSNLKLTLTT ALALISILTA GLAYEWFQKG LEWEE //