ID Q00I03_LEPAN Unreviewed; 115 AA. AC Q00I03; DT 14-NOV-2006, integrated into UniProtKB/TrEMBL. DT 14-NOV-2006, sequence version 1. DT 17-FEB-2016, entry version 37. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|RuleBase:RU003640, ECO:0000256|SAAS:SAAS00136968}; DE EC=1.6.5.3 {ECO:0000256|RuleBase:RU003640}; OS Lepilemur ankaranensis (Ankarana sportive lemur) (Lepilemur OS septentrionalis ankaranensis). OG Mitochondrion {ECO:0000313|EMBL:ABG73826.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lemuriformes; Lepilemuridae; Lepilemur. OX NCBI_TaxID=342401 {ECO:0000313|EMBL:ABG73826.1}; RN [1] {ECO:0000313|EMBL:ABG73826.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DAR4.35 {ECO:0000313|EMBL:ABG73826.1}; RA Louis E.E. Jr, Engberg S.E., Lei R., Geng H., Sommer J.A., RA Randriamampionona R., Randriamanana J.C., Zaonarivelo J.R., RA Andriantompohavana R., Randria G., Prosper, Ramaromilanto B., RA Rakotoarisoa G., Rooney A., Brenneman R.A.; RT "Molecular and morphological analyses of the sportive lemurs (Family RT Megaladapidae: Genus Lepilemur) reveals 11 previously unrecognized RT species."; RL Spec. Publ. Mus. Tex. Tech. Univ. 49:1-47(2006). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). {ECO:0000256|SAAS:SAAS00210153}. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003640, CC ECO:0000256|SAAS:SAAS00136991}. CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|SAAS:SAAS00136948}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00136948}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC {ECO:0000256|RuleBase:RU003640}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ529627; ABG73826.1; -; Genomic_DNA. DR HOVERGEN; HBG017392; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR PANTHER; PTHR11058; PTHR11058; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|SAAS:SAAS00488186}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU003640, KW ECO:0000256|SAAS:SAAS00488193, ECO:0000313|EMBL:ABG73826.1}; KW NAD {ECO:0000256|RuleBase:RU003640, ECO:0000256|SAAS:SAAS00488202}; KW Oxidoreductase {ECO:0000256|RuleBase:RU003640}; KW Respiratory chain {ECO:0000256|SAAS:SAAS00488192}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|SAAS:SAAS00488192}; KW Ubiquinone {ECO:0000256|RuleBase:RU003640, KW ECO:0000256|SAAS:SAAS00488191}. FT TRANSMEM 7 24 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 55 79 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 86 107 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 115 AA; 13094 MW; C4EB968D96D9FA91 CRC64; MNLPLTITIN TLMVTILVMI AFWLPQLNVY TEKYNPYECG FDPMGSARLP FSMKFFLVAI TFLLFDLGIA LLLPLPWAIQ MSNLKLTLTT ALALISILTA GLAYEWFQKG LEWEE //