ID Q00GN8_LEPAN Unreviewed; 459 AA. AC Q00GN8; DT 14-NOV-2006, integrated into UniProtKB/TrEMBL. DT 14-NOV-2006, sequence version 1. DT 10-APR-2019, entry version 63. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003297}; GN Name=ND4 {ECO:0000313|EMBL:ADP68072.1}; OS Lepilemur ankaranensis (Ankarana sportive lemur) (Lepilemur OS septentrionalis ankaranensis). OG Mitochondrion {ECO:0000313|EMBL:ABG74291.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lemuriformes; Lepilemuridae; Lepilemur. OX NCBI_TaxID=342401 {ECO:0000313|EMBL:ABG74291.1}; RN [1] {ECO:0000313|EMBL:ABG74291.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FIA5.1 {ECO:0000313|EMBL:ABG74175.1}, FIA5.11 RC {ECO:0000313|EMBL:ABG74203.1}, FIA5.12 {ECO:0000313|EMBL:ABG74207.1}, RC FIA5.13 {ECO:0000313|EMBL:ABG74211.1}, FIA5.5 RC {ECO:0000313|EMBL:ABG74179.1}, FIA5.6 {ECO:0000313|EMBL:ABG74183.1}, RC FIA5.9 {ECO:0000313|EMBL:ABG74195.1}, LABE5.1 RC {ECO:0000313|EMBL:ABG74275.1}, LABE5.17 {ECO:0000313|EMBL:ABG74291.1}, RC LABE5.2 {ECO:0000313|EMBL:ABG74279.1}, LABE5.3 RC {ECO:0000313|EMBL:ABG74283.1}, LABE5.4 {ECO:0000313|EMBL:ABG74287.1}, RC LAME5.6 {ECO:0000313|EMBL:ABG74167.1}, and LAME5.8 RC {ECO:0000313|EMBL:ABG74171.1}; RA Louis E.E.Jr., Engberg S.E., Lei R., Geng H., Sommer J.A., RA Randriamampionona R., Randriamanana J.C., Zaonarivelo J.R., RA Andriantompohavana R., Randria G., Prosper, Ramaromilanto B., RA Rakotoarisoa G., Rooney A., Brenneman R.A.; RT "Molecular and morphological analyses of the sportive lemurs (Family RT Megaladapidae: Genus Lepilemur) reveals 11 previously unrecognized RT species."; RL Spec. Publ. Mus. Tex. Tech. Univ. 49:1-47(2006). RN [2] {ECO:0000313|EMBL:ADP68072.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ANAL5 {ECO:0000313|EMBL:ADP68072.1}; RX PubMed=28173059; DOI=10.1093/jhered/esw072; RA Lei R., Frasier C.L., Hawkins M.T., Engberg S.E., Bailey C.A., RA Johnson S.E., McLain A.T., Groves C.P., Perry G.H., Nash S.D., RA Mittermeier R.A., Louis E.E.; RT "Phylogenomic Reconstruction of Sportive Lemurs (genus Lepilemur) RT Recovered from Mitogenomes with Inferences for Madagascar RT Biogeography."; RL J. Hered. 108:107-119(2017). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003297}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003297}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003297}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003297}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707377}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ529712; ABG74167.1; -; Genomic_DNA. DR EMBL; DQ529713; ABG74171.1; -; Genomic_DNA. DR EMBL; DQ529714; ABG74175.1; -; Genomic_DNA. DR EMBL; DQ529715; ABG74179.1; -; Genomic_DNA. DR EMBL; DQ529716; ABG74183.1; -; Genomic_DNA. DR EMBL; DQ529719; ABG74195.1; -; Genomic_DNA. DR EMBL; DQ529721; ABG74203.1; -; Genomic_DNA. DR EMBL; DQ529722; ABG74207.1; -; Genomic_DNA. DR EMBL; DQ529723; ABG74211.1; -; Genomic_DNA. DR EMBL; DQ529739; ABG74275.1; -; Genomic_DNA. DR EMBL; DQ529740; ABG74279.1; -; Genomic_DNA. DR EMBL; DQ529741; ABG74283.1; -; Genomic_DNA. DR EMBL; DQ529742; ABG74287.1; -; Genomic_DNA. DR EMBL; DQ529743; ABG74291.1; -; Genomic_DNA. DR EMBL; HQ171056; ADP68072.1; -; Genomic_DNA. DR HOVERGEN; HBG093667; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR PANTHER; PTHR43507; PTHR43507; 1. DR Pfam; PF01059; Oxidored_q5_N; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. DR TIGRFAMs; TIGR01972; NDH_I_M; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003297}; KW Membrane {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707373}; KW Mitochondrion {ECO:0000256|RuleBase:RU003297, KW ECO:0000313|EMBL:ABG74291.1}; KW NAD {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707374}; KW Respiratory chain {ECO:0000256|RuleBase:RU003297}; KW Translocase {ECO:0000256|SAAS:SAAS01135314}; KW Transmembrane {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707385}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707361}; KW Transport {ECO:0000256|RuleBase:RU003297}; KW Ubiquinone {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00699082}. FT TRANSMEM 94 110 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 116 133 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 145 167 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 194 216 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 223 244 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 256 277 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 284 303 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 309 330 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 351 373 Helical. {ECO:0000256|RuleBase:RU003297}. FT DOMAIN 1 109 Oxidored_q5_N. {ECO:0000259|Pfam: FT PF01059}. FT DOMAIN 112 403 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. SQ SEQUENCE 459 AA; 52177 MW; 3BEAEAD636206142 CRC64; MLKIIIPTIM LLPVTWFSAN SMVWINITLH SLTISLMSLS FLNQTDSNSN NFSSTFFSDP LSSPLLTLTM WLLPLTIMAS QHHLSKEPWE RKKYFLFTLI SLQLFLIMTF TATELIMFYI LFESTLIPTL IIITRWGNQT ERLNAGLYFL FYTLIGSLPL LVALSFIQKH MGTLNLFMMT YWSQELPNSW SSNLMWMACI MAFMIKMPLY GLHLWLPKAH VEAPIAGSMI LAAILLKLGG YGMMRITTIL NPLTKFMAYP FLMLCLWGMI MTSLICLRQT DLKSLIAYSS VSHMALVIVA ILIQTPWSFM GATALMIAHG LTSSMLFCLA NSNYERIHNR TMLLARGLQS LLPLMSTWWL LASLTNLALP PSINLIGELF ITMATFSWSN MTIILTGLNM LITATYSLHM LAMTQRGKSL YHMHNLNPSL TRENTLMSMH IFPLLLLTLN PNILMGPTY //