ID Y1319_MYCTO Reviewed; 558 AA. AC P9WQ30; L0T6A5; P0A4Y2; Q10632; DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot. DT 16-APR-2014, sequence version 1. DT 14-DEC-2022, entry version 33. DE RecName: Full=Uncharacterized protein MT1361; GN OrderedLocusNames=MT1361; OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh). OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium; Mycobacterium tuberculosis complex. OX NCBI_TaxID=83331; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CDC 1551 / Oshkosh; RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002; RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.; RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and RT laboratory strains."; RL J. Bacteriol. 184:5479-5490(2002). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE000516; AAK45623.1; -; Genomic_DNA. DR PIR; C70769; C70769. DR RefSeq; WP_003910324.1; NC_002755.2. DR AlphaFoldDB; P9WQ30; -. DR SMR; P9WQ30; -. DR EnsemblBacteria; AAK45623; AAK45623; MT1361. DR GeneID; 45425296; -. DR KEGG; mtc:MT1361; -. DR HOGENOM; CLU_025433_2_1_11; -. DR Proteomes; UP000001020; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt. DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR CDD; cd07302; CHD; 1. DR Gene3D; 3.30.70.1230; -; 1. DR InterPro; IPR001054; A/G_cyclase. DR InterPro; IPR003660; HAMP_dom. DR InterPro; IPR029787; Nucleotide_cyclase. DR Pfam; PF00211; Guanylate_cyc; 1. DR Pfam; PF00672; HAMP; 1. DR SMART; SM00044; CYCc; 1. DR SMART; SM00304; HAMP; 1. DR SUPFAM; SSF55073; Nucleotide cyclase; 1. DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1. DR PROSITE; PS50885; HAMP; 1. PE 3: Inferred from homology; KW Cell membrane; Membrane; Transmembrane; Transmembrane helix. FT CHAIN 1..558 FT /note="Uncharacterized protein MT1361" FT /id="PRO_0000426847" FT TRANSMEM 63..83 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 90..110 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 143..163 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 168..188 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 226..246 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 258..278 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 279..330 FT /note="HAMP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102" FT DOMAIN 362..486 FT /note="Guanylate cyclase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00099" FT REGION 529..558 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 541..558 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 558 AA; 60721 MW; 196F00626839B8EE CRC64; MPAKKTMAQR LGQALETMTR QCGQLPETPA YGSWLLGRVS ESPSRRWVRI KRIVTVYIMT ANLTGIVVAL LVVTFAFPVP SIYTDAPWWV TFGVAPAYAT LALAIGTYWI TTRIVRASIR WAIEERAPSQ ADGRNTLLLP FRVAAVHLIL WDIGGALLAT LYGLANRVFV TIILFSVTIC GVLVATNCYL FTEFALRPVA AKALEAGRPP RRFAPGIMGR TMTVWSLGSG VPVTGIATTA LYVLLVHNLT ETQLASAVLI LSITTLIFGF LVMWILAWLT AAPVRVVRAA LKRVEQGDLR GDLVVFDGTE LGELQRGFNA MVNGLRERER VRDLFGRHVG REVAAAAERE RPQLGGEDRH AAVVFVDIVG STQLVDNQPA AHVVKLLNRF FAIVVNEVDR HHGLINKFAG DAALAIFGAP NRLDRPEDAA LAAARAIADR LANEMPEVQA GIGVAAGQIV AGNVGAKQRF EYTVVGKPVN QAARLCELAK SHPARLLASS DTLHAASETE RAHWSLGETV TLRGYHQPTQ LASPHRRPPG SIHLTAEHAE EIRTDRLG //