ID Y1319_MYCTO Reviewed; 558 AA. AC P9WQ30; L0T6A5; P0A4Y2; Q10632; DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot. DT 16-APR-2014, sequence version 1. DT 24-JUN-2015, entry version 11. DE RecName: Full=Uncharacterized protein MT1361; GN OrderedLocusNames=MT1361; OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh). OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium; Mycobacterium tuberculosis complex. OX NCBI_TaxID=83331; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CDC 1551 / Oshkosh; RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002; RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., RA Fraser C.M.; RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and RT laboratory strains."; RL J. Bacteriol. 184:5479-5490(2002). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass CC membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family. CC {ECO:0000305}. CC -!- SIMILARITY: Contains 1 guanylate cyclase domain. CC {ECO:0000255|PROSITE-ProRule:PRU00099}. CC -!- SIMILARITY: Contains 1 HAMP domain. {ECO:0000255|PROSITE- CC ProRule:PRU00102}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE000516; AAK45623.1; -; Genomic_DNA. DR PIR; C70769; C70769. DR RefSeq; NP_335809.1; NC_002755.2. DR RefSeq; WP_003910324.1; NC_002755.2. DR EnsemblBacteria; AAK45623; AAK45623; MT1361. DR KEGG; mtc:MT1361; -. DR KO; K01768; -. DR Proteomes; UP000001020; Chromosome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR Gene3D; 3.30.70.1230; -; 1. DR InterPro; IPR001054; A/G_cyclase. DR InterPro; IPR003660; HAMP_linker_domain. DR InterPro; IPR029787; Nucleotide_cyclase. DR Pfam; PF00211; Guanylate_cyc; 1. DR Pfam; PF00672; HAMP; 1. DR SMART; SM00044; CYCc; 1. DR SMART; SM00304; HAMP; 1. DR SUPFAM; SSF55073; SSF55073; 1. DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1. DR PROSITE; PS50885; HAMP; 1. PE 3: Inferred from homology; KW Cell membrane; Complete proteome; Membrane; Transmembrane; KW Transmembrane helix. FT CHAIN 1 558 Uncharacterized protein MT1361. FT /FTId=PRO_0000426847. FT TRANSMEM 63 83 Helical. {ECO:0000255}. FT TRANSMEM 90 110 Helical. {ECO:0000255}. FT TRANSMEM 143 163 Helical. {ECO:0000255}. FT TRANSMEM 168 188 Helical. {ECO:0000255}. FT TRANSMEM 226 246 Helical. {ECO:0000255}. FT TRANSMEM 258 278 Helical. {ECO:0000255}. FT DOMAIN 279 330 HAMP. {ECO:0000255|PROSITE- FT ProRule:PRU00102}. FT DOMAIN 362 486 Guanylate cyclase. {ECO:0000255|PROSITE- FT ProRule:PRU00099}. SQ SEQUENCE 558 AA; 60721 MW; 196F00626839B8EE CRC64; MPAKKTMAQR LGQALETMTR QCGQLPETPA YGSWLLGRVS ESPSRRWVRI KRIVTVYIMT ANLTGIVVAL LVVTFAFPVP SIYTDAPWWV TFGVAPAYAT LALAIGTYWI TTRIVRASIR WAIEERAPSQ ADGRNTLLLP FRVAAVHLIL WDIGGALLAT LYGLANRVFV TIILFSVTIC GVLVATNCYL FTEFALRPVA AKALEAGRPP RRFAPGIMGR TMTVWSLGSG VPVTGIATTA LYVLLVHNLT ETQLASAVLI LSITTLIFGF LVMWILAWLT AAPVRVVRAA LKRVEQGDLR GDLVVFDGTE LGELQRGFNA MVNGLRERER VRDLFGRHVG REVAAAAERE RPQLGGEDRH AAVVFVDIVG STQLVDNQPA AHVVKLLNRF FAIVVNEVDR HHGLINKFAG DAALAIFGAP NRLDRPEDAA LAAARAIADR LANEMPEVQA GIGVAAGQIV AGNVGAKQRF EYTVVGKPVN QAARLCELAK SHPARLLASS DTLHAASETE RAHWSLGETV TLRGYHQPTQ LASPHRRPPG SIHLTAEHAE EIRTDRLG //