ID P97483_MOUSE Unreviewed; 103 AA. AC P97483; DT 01-MAY-1997, integrated into UniProtKB/TrEMBL. DT 01-MAY-1997, sequence version 1. DT 27-MAY-2015, entry version 74. DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633}; DE Flags: Fragment; GN Name=Itgb3 {ECO:0000313|MGI:MGI:96612}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAB40933.1}; RN [1] {ECO:0000313|EMBL:AAB40933.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:AAB40933.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:AAB40933.1}; RA Barron-Casella E.A., Casella J.F., Rogers O.C.; RT "5' end of the murine glycoprotein IIIa."; RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU000633}. CC -!- SIMILARITY: Belongs to the integrin beta chain family. CC {ECO:0000256|RuleBase:RU000633}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U83167; AAB40933.1; -; mRNA. DR UniGene; Mm.87150; -. DR MGI; MGI:96612; Itgb3. DR ChiTaRS; Itgb3; mouse. DR Genevestigator; P97483; -. DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0070062; C:extracellular exosome; ISO:MGI. DR GO; GO:0031527; C:filopodium membrane; ISO:MGI. DR GO; GO:0005925; C:focal adhesion; ISO:MGI. DR GO; GO:0034683; C:integrin alphav-beta3 complex; ISO:MGI. DR GO; GO:0008305; C:integrin complex; ISO:MGI. DR GO; GO:0031258; C:lamellipodium membrane; ISO:MGI. DR GO; GO:0042470; C:melanosome; ISO:MGI. DR GO; GO:0031528; C:microvillus membrane; ISO:MGI. DR GO; GO:0005634; C:nucleus; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; ISO:MGI. DR GO; GO:0043235; C:receptor complex; ISO:MGI. DR GO; GO:0032587; C:ruffle membrane; ISO:MGI. DR GO; GO:0050839; F:cell adhesion molecule binding; ISO:MGI. DR GO; GO:0050840; F:extracellular matrix binding; ISO:MGI. DR GO; GO:0001968; F:fibronectin binding; ISO:MGI. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0005178; F:integrin binding; IPI:MGI. DR GO; GO:0002020; F:protease binding; ISO:MGI. DR GO; GO:0003756; F:protein disulfide isomerase activity; ISO:MGI. DR GO; GO:0004872; F:receptor activity; IEA:InterPro. DR GO; GO:0043184; F:vascular endothelial growth factor receptor 2 binding; ISO:MGI. DR GO; GO:0032147; P:activation of protein kinase activity; ISO:MGI. DR GO; GO:0060055; P:angiogenesis involved in wound healing; IEA:InterPro. DR GO; GO:0038027; P:apolipoprotein A-I-mediated signaling pathway; ISO:MGI. DR GO; GO:0016049; P:cell growth; ISO:MGI. DR GO; GO:0016477; P:cell migration; ISO:MGI. DR GO; GO:0007160; P:cell-matrix adhesion; IGI:MGI. DR GO; GO:0031589; P:cell-substrate adhesion; ISO:MGI. DR GO; GO:0007044; P:cell-substrate junction assembly; IDA:MGI. DR GO; GO:0034113; P:heterotypic cell-cell adhesion; ISO:MGI. DR GO; GO:0007229; P:integrin-mediated signaling pathway; ISO:MGI. DR GO; GO:0050919; P:negative chemotaxis; ISO:MGI. DR GO; GO:0010888; P:negative regulation of lipid storage; ISO:MGI. DR GO; GO:0032369; P:negative regulation of lipid transport; ISO:MGI. DR GO; GO:0050748; P:negative regulation of lipoprotein metabolic process; ISO:MGI. DR GO; GO:0045715; P:negative regulation of low-density lipoprotein particle receptor biosynthetic process; ISO:MGI. DR GO; GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; ISO:MGI. DR GO; GO:0030168; P:platelet activation; ISO:MGI. DR GO; GO:0070527; P:platelet aggregation; ISO:MGI. DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:MGI. DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI. DR GO; GO:0006457; P:protein folding; ISO:MGI. DR GO; GO:0030334; P:regulation of cell migration; IMP:MGI. DR GO; GO:0014909; P:smooth muscle cell migration; ISO:MGI. DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; ISO:MGI. DR GO; GO:0046718; P:viral entry into host cell; ISO:MGI. DR InterPro; IPR027068; Integrin_beta-3. DR InterPro; IPR015812; Integrin_bsu. DR InterPro; IPR002369; Integrin_bsu_N. DR InterPro; IPR016201; Plexin-like_fold. DR PANTHER; PTHR10082; PTHR10082; 1. DR PANTHER; PTHR10082:SF25; PTHR10082:SF25; 1. DR Pfam; PF00362; Integrin_beta; 1. DR PRINTS; PR01186; INTEGRINB. DR SMART; SM00423; PSI; 1. DR SUPFAM; SSF103575; SSF103575; 1. PE 2: Evidence at transcript level; KW Cell adhesion {ECO:0000256|RuleBase:RU000633}; KW Integrin {ECO:0000256|RuleBase:RU000633}; KW Membrane {ECO:0000256|RuleBase:RU000633}; KW Transmembrane {ECO:0000256|RuleBase:RU000633}. FT NON_TER 103 103 {ECO:0000313|EMBL:AAB40933.1}. SQ SEQUENCE 103 AA; 10748 MW; 1E554533AEE1DA66 CRC64; MRAQWPGQLW AALLALGALA GVVVGESNIC TARGVNSCQQ CLAVSPVCAW CSDETLSQGS PRCNLKENLL KDNCAPESIE FPVSEAQILE ARPLSSKGSG SSA //