ID PIX2_MOUSE STANDARD; PRT; 317 AA. AC P97474; O08646; P97933; O70336; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE PITUITARY HOMEOBOX 2 (ORTHODENTICLE-LIKE HOMEOBOX 2) (SOLURSHIN) DE (ALL1 RESPONSIVE PROTEIN ARP1). GN PITX2 OR PTX2 OR OTLX2 OR RGS OR ARP1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. (ISOFORM PTX2A). RA Mucchielli M.L., Martinez S., Pattyn A., Goridis C., Brunet J.F.; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. (ISOFORMS PTX2A AND PTX2B). RC TISSUE=PITUITARY; RX MEDLINE=97227292; PubMed=9147650; RA Gage P.J., Camper S.A.; RT "Pituitary homeobox 2, a novel member of the bicoid-related family of RT homeobox genes, is a potential regulator of anterior structure RT formation."; RL Hum. Mol. Genet. 6:457-464(1997). RN [3] RP SEQUENCE FROM N.A. (ISOFORMS PTX2A AND PTX2C). RX MEDLINE=98208582; PubMed=9539779; RA Arakawa H., Nakamura T., Zhadanov A.B., Fidanza Y., Yano T., RA Bullrich F., Shimizu M., Blechman J., Mazo A., Canaani E., RA Croce C.M.; RT "Identification and characterization of the ARP1 gene, a target for RT the human acute leukemia ALL1 gene."; RL Proc. Natl. Acad. Sci. U.S.A. 95:4573-4578(1998). RN [4] RP SEQUENCE OF 63-317 FROM N.A. RC TISSUE=EMBRYONIC CARCINOMA; RX MEDLINE=97099449; PubMed=8944018; RA Semina E.V., Reiter R., Leysens N.J., Alward W.L.M., Small K.W., RA Datson N.A., Siegle-Bartelt J., Bierke-Nelson D., Bitoun P., RA Zabel B.U., Carey J.C., Murray J.C.; RT "Cloning and characterization of a novel bicoid-related homeobox RT transcription factor gene, RIEG, involved in Rieger syndrome."; RL Nat. Genet. 14:392-399(1996). CC -!- FUNCTION: MAY PLAY AN IMPORTANT ROLE IN DEVELOPMENT AND CC MAINTENANCE OF ANTERIOR STRUCTURES. CC -!- SUBCELLULAR LOCATION: NUCLEAR (PROBABLE). CC -!- ALTERNATIVE PRODUCTS: 3 ISOFORMS; PTX2B/ARP1B (SHOWN HERE), CC PTX2C/ARP1C AND PTX2A/ARP1A; ARE PRODUCED BY ALTERNATIVE SPLICING. CC -!- TISSUE SPECIFICITY: IN DAY-11 EMBRYOS, EXPRESSED IN THE CC PERIOCULAR MESENCHYME, MAXILLARY AND MANDIBULAR EPITHELIA, CC UMBILICUS, RATHKE'S POUCH, VITELLINE VESSELS AND LIMB MESENCHYME. CC IN ADULT TISSUES, EXPRESSED IN PITUITARY GLAND, BRAIN, KIDNEY, CC EYE, LUNG, TESTIS AND TONGUE. CC -!- SIMILARITY: BELONGS TO THE PAIRED FAMILY OF HOMEOBOX PROTEINS. CC "BICOID" SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U80036; AAB38505.1; -. DR EMBL; U80010; AAC53119.1; -. DR EMBL; U80011; AAC53120.1; -. DR EMBL; AF048723; AAC40086.1; -. DR EMBL; AF048724; AAC40087.1; -. DR EMBL; U70132; AAB38864.1; -. DR HSSP; P06601; 1FJL. DR MGD; MGI:109340; PITX2. DR INTERPRO; IPR001356; -. DR PFAM; PF00046; homeobox; 1. DR PRINTS; PR00024; HOMEOBOX. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW Homeobox; DNA-binding; Developmental protein; Nuclear protein; KW Alternative splicing. FT DNA_BIND 85 144 HOMEOBOX. FT VARSPLIC 16 61 MISSING (IN ISOFORM PTX2A). FT VARSPLIC 1 61 METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSP FT KSRKESASSKLFPRQHPGAN -> MNCMKGPLPLEHRAAGT FT KLSAASSPFCHHPQALAMASVLAPGQPRSLDSSKHRLEVHT FT ISDTSSPEVA (IN ISOFORM PTX2C). SQ SEQUENCE 317 AA; 35320 MW; 188315708E6BD95D CRC64; METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PKSRKESASS KLFPRQHPGA NEKDKGQQGK NEDVGAEDPS KKKRQRRQRT HFTSQQLQEL EATFQRNRYP DMSTREEIAV WTNLTEARVR VWFKNRRAKW RKRERNQQAE LCKNGFGPQF NGLMQPYDDM YPGYSYNNWA AKGLTSASLS TKSFPFFNSM NVNPLSSQSM FSPPNSISSM SMSSSMVPSA VTGVPGSSLN SLNNLNNLSS PSLNSAVPTP ACPYAPPTPP YVYRDTCNSS LASLRLKAKQ HSSFGYASVQ NPASNLSACQ YAVDRPV //