ID PITX2_MOUSE Reviewed; 317 AA. AC P97474; O08646; O70336; P97933; Q9JLA0; Q9QXB8; Q9R1V9; Q9Z141; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1999, sequence version 2. DT 31-OCT-2006, entry version 58. DE Pituitary homeobox 2 (Orthodenticle-like homeobox 2) (Solurshin) DE (ALL1-responsive protein ARP1) (BRX1 homeoprotein) (Paired-like DE homeodomain transcription factor Munc 30). GN Name=Pitx2; Synonyms=Arp1, Brx1, Otlx2, Ptx2, Rgs; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PTX2A). RA Mucchielli M.L., Martinez S., Pattyn A., Goridis C., Brunet J.F.; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PTX2A AND PTX2B). RC TISSUE=Pituitary; RX MEDLINE=97227292; PubMed=9147650; DOI=10.1093/hmg/6.3.457; RA Gage P.J., Camper S.A.; RT "Pituitary homeobox 2, a novel member of the bicoid-related family of RT homeobox genes, is a potential regulator of anterior structure RT formation."; RL Hum. Mol. Genet. 6:457-464(1997). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PTX2B AND PTX2C). RX MEDLINE=98006140; PubMed=9347917; DOI=10.1016/S0925-4773(97)00110-X; RA Kitamura K., Miura H., Yanazawa M., Miyashita T., Kato K.; RT "Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 RT and Arx during zona limitans intrathalamica and embryonic ventral RT lateral geniculate nuclear formation."; RL Mech. Dev. 67:83-96(1997). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PTX2A AND PTX2C). RX MEDLINE=98208582; PubMed=9539779; DOI=10.1073/pnas.95.8.4573; RA Arakawa H., Nakamura T., Zhadanov A.B., Fidanza Y., Yano T., RA Bullrich F., Shimizu M., Blechman J., Mazo A., Canaani E., Croce C.M.; RT "Identification and characterization of the ARP1 gene, a target for RT the human acute leukemia ALL1 gene."; RL Proc. Natl. Acad. Sci. U.S.A. 95:4573-4578(1998). RN [5] RP PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM PTX2C). RX MEDLINE=20054091; PubMed=10585561; DOI=10.1016/S0925-4773(99)00227-0; RA Schweickert A., Campione M., Steinbeisser H., Blum M.; RT "Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in RT vertebrate left-right asymmetry."; RL Mech. Dev. 90:41-51(2000). RN [6] RP PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM PTX2C). RX MEDLINE=21220725; PubMed=11319841; DOI=10.1006/cbir.2000.0638; RA Nicholson L.F.B., Ma L., Goulding M.; RT "Cloning and expression of Munc 30: a member of the paired-like RT homeodomain gene family."; RL Cell Biol. Int. 25:351-365(2001). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] OF 63-317. RC TISSUE=Embryonic carcinoma; RX MEDLINE=97099449; PubMed=8944018; DOI=10.1038/ng1296-392; RA Semina E.V., Reiter R., Leysens N.J., Alward W.L.M., Small K.W., RA Datson N.A., Siegle-Bartelt J., Bierke-Nelson D., Bitoun P., RA Zabel B.U., Carey J.C., Murray J.C.; RT "Cloning and characterization of a novel bicoid-related homeobox RT transcription factor gene, RIEG, involved in Rieger syndrome."; RL Nat. Genet. 14:392-399(1996). CC -!- FUNCTION: May play an important role in development and CC maintenance of anterior structures. Isoform Ptx2c is involved in CC left-right asymmetry in the developing embryo. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=Ptx2B; Synonyms=ARP1B, BRX1B; CC IsoId=P97474-1; Sequence=Displayed; CC Name=Ptx2C; Synonyms=ARP1C, BRX1A; CC IsoId=P97474-2; Sequence=VSP_002262; CC Name=Ptx2A; Synonyms=ARP1A; CC IsoId=P97474-3; Sequence=VSP_002263; CC -!- TISSUE SPECIFICITY: In day-11 embryos, expressed in the periocular CC mesenchyme, maxillary and mandibular epithelia, umbilicus, Rathke CC pouch, vitelline vessels and limb mesenchyme. In adult tissues, CC expressed in pituitary gland, brain, kidney, eye, lung, testis and CC tongue. CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid CC subfamily. CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain. CC -!- SIMILARITY: Contains 1 OAR domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U80036; AAB38505.1; -; mRNA. DR EMBL; U80010; AAC53119.1; -; mRNA. DR EMBL; U80011; AAC53120.1; -; mRNA. DR EMBL; AB006320; BAA75247.1; -; mRNA. DR EMBL; AB006321; BAA75248.1; -; mRNA. DR EMBL; AF048723; AAC40086.1; -; mRNA. DR EMBL; AF048724; AAC40087.1; -; mRNA. DR EMBL; AJ243597; CAB65259.1; -; mRNA. DR EMBL; AF201091; AAF44618.1; ALT_INIT; mRNA. DR EMBL; U70132; AAB38864.1; -; mRNA. DR UniGene; Mm.246804; -. DR HSSP; P06601; 1FJL. DR SMR; P97474; 85-144. DR TRANSFAC; T02410; -. DR Ensembl; ENSMUSG00000028023; Mus musculus. DR KEGG; mmu:18741; -. DR MGI; MGI:109340; Pitx2. DR ArrayExpress; P97474; -. DR GO; GO:0005667; C:transcription factor complex; IDA:MGI. DR GO; GO:0005515; F:protein binding; IPI:MGI. DR GO; GO:0003700; F:transcription factor activity; IDA:MGI. DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI. DR GO; GO:0002074; P:extraocular skeletal muscle development (se...; IMP:MGI. DR GO; GO:0007507; P:heart development; IMP:MGI. DR GO; GO:0007389; P:pattern specification; IMP:MGI. DR GO; GO:0001569; P:patterning of blood vessels; IMP:MGI. DR GO; GO:0030334; P:regulation of cell migration; IMP:MGI. DR GO; GO:0042127; P:regulation of cell proliferation; IMP:MGI. DR GO; GO:0045449; P:regulation of transcription; IDA:MGI. DR GO; GO:0016055; P:Wnt receptor signaling pathway; IDA:MGI. DR InterPro; IPR003654; Homeo_OAR. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR012287; Homeodomain-rel. DR InterPro; IPR009057; Homeodomain_like. DR Pfam; PF00046; Homeobox; 1. DR Pfam; PF03826; OAR; 1. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS50803; OAR; 1. KW Alternative splicing; Developmental protein; DNA-binding; Homeobox; KW Nuclear protein. FT CHAIN 1 317 Pituitary homeobox 2. FT /FTId=PRO_0000049224. FT DNA_BIND 85 144 Homeobox. FT MOTIF 279 292 OAR. FT MOTIF 285 289 Nuclear localization signal (Potential). FT VAR_SEQ 1 61 METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSP FT KSRKESASSKLFPRQHPGAN -> MNCMKGPLPLEHRAAGT FT KLSAASSPFCHHPQALAMASVLAPGQPRSLDSSKHRLEVHT FT ISDTSSPEVA (in isoform Ptx2C). FT /FTId=VSP_002262. FT VAR_SEQ 16 61 Missing (in isoform Ptx2A). FT /FTId=VSP_002263. FT CONFLICT 187 187 A -> T (in Ref. 3). SQ SEQUENCE 317 AA; 35321 MW; 188315708E6BD95D CRC64; METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PKSRKESASS KLFPRQHPGA NEKDKGQQGK NEDVGAEDPS KKKRQRRQRT HFTSQQLQEL EATFQRNRYP DMSTREEIAV WTNLTEARVR VWFKNRRAKW RKRERNQQAE LCKNGFGPQF NGLMQPYDDM YPGYSYNNWA AKGLTSASLS TKSFPFFNSM NVNPLSSQSM FSPPNSISSM SMSSSMVPSA VTGVPGSSLN SLNNLNNLSS PSLNSAVPTP ACPYAPPTPP YVYRDTCNSS LASLRLKAKQ HSSFGYASVQ NPASNLSACQ YAVDRPV //