ID ZNT3_MOUSE STANDARD; PRT; 388 AA. AC P97441; P97511; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Zinc transporter 3 (ZnT-3). GN Name=Slc30a3; Synonyms=Znt3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION. RC STRAIN=129; TISSUE=Brain; RX MEDLINE=97121493; PubMed=8962159; DOI=10.1073/pnas.93.25.14934; RA Palmiter R.D., Cole T.B., Quaife C.J., Findley S.D.; RT "ZnT-3, a putative transporter of zinc into synaptic vesicles."; RL Proc. Natl. Acad. Sci. U.S.A. 93:14934-14939(1996). CC -!- FUNCTION: Involved in accumulation of zinc in synaptic vesicles. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. Localized in the CC membrane of synaptic vesicles (Probable). CC -!- TISSUE SPECIFICITY: Brain and testis. In the brain, most abundant CC in hippocampus and cerebral cortex. In the testis, expression is CC restricted to germ cells and is highest in pachytene spermatocytes CC and round spermatids. CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF) CC transporter (TC 2.A.4) family. SLC30A subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U76007; AAB39731.1; -. DR EMBL; U76009; AAB39733.1; ALT_SEQ. DR EMBL; U76008; AAB39733.1; JOINED. DR MGD; MGI:1345280; Slc30a3. DR GO; GO:0016021; C:integral to membrane; TAS. DR InterPro; IPR002524; Cation_efflux. DR Pfam; PF01545; Cation_efflux; 1. DR TIGRFAMs; TIGR01297; CDF; 1. KW Multigene family; Transmembrane; Transport; Zinc transport. FT DOMAIN 1 75 Cytoplasmic (Potential). FT TRANSMEM 76 96 Potential. FT DOMAIN 97 105 Vacuolar (Potential). FT TRANSMEM 106 126 Potential. FT DOMAIN 127 145 Cytoplasmic (Potential). FT TRANSMEM 146 166 Potential. FT DOMAIN 167 177 Vacuolar (Potential). FT TRANSMEM 178 198 Potential. FT DOMAIN 199 235 Cytoplasmic (Potential). FT TRANSMEM 236 256 Potential. FT DOMAIN 257 263 Vacuolar (Potential). FT TRANSMEM 264 284 Potential. FT DOMAIN 285 388 Cytoplasmic (Potential). SQ SEQUENCE 388 AA; 41824 MW; 3CCDD0A37074EF41 CRC64; MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM AFHHCHKDPV PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL AIMTDAAHLL ADIGSMLASL FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NLLMAFVLHQ TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL GDLLQSFGVL AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPSQA //