ID ZNT3_MOUSE Reviewed; 388 AA. AC P97441; P97511; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 03-OCT-2012, entry version 102. DE RecName: Full=Zinc transporter 3; DE Short=ZnT-3; DE AltName: Full=Solute carrier family 30 member 3; GN Name=Slc30a3; Synonyms=Znt3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND CHARACTERIZATION. RC STRAIN=129; TISSUE=Brain; RX MEDLINE=97121493; PubMed=8962159; DOI=10.1073/pnas.93.25.14934; RA Palmiter R.D., Cole T.B., Quaife C.J., Findley S.D.; RT "ZnT-3, a putative transporter of zinc into synaptic vesicles."; RL Proc. Natl. Acad. Sci. U.S.A. 93:14934-14939(1996). RN [2] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND MASS RP SPECTROMETRY. RC TISSUE=Brain cortex; RX PubMed=17114649; DOI=10.1074/mcp.M600046-MCP200; RA Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., RA Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., RA Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; RT "Qualitative and quantitative analyses of protein phosphorylation in RT naive and stimulated mouse synaptosomal preparations."; RL Mol. Cell. Proteomics 6:283-293(2007). CC -!- FUNCTION: Involved in accumulation of zinc in synaptic vesicles. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, CC synaptic vesicle membrane; Multi-pass membrane protein (Probable). CC -!- TISSUE SPECIFICITY: Brain and testis. In the brain, most abundant CC in hippocampus and cerebral cortex. In the testis, expression is CC restricted to germ cells and is highest in pachytene spermatocytes CC and round spermatids. CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF) CC transporter (TC 2.A.4) family. SLC30A subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U76007; AAB39731.1; -; mRNA. DR EMBL; U76009; AAB39733.1; ALT_SEQ; Genomic_DNA. DR EMBL; U76008; AAB39733.1; JOINED; Genomic_DNA. DR IPI; IPI00125397; -. DR RefSeq; NP_035903.2; NM_011773.3. DR UniGene; Mm.1396; -. DR ProteinModelPortal; P97441; -. DR IntAct; P97441; 1. DR STRING; P97441; -. DR PhosphoSite; P97441; -. DR PRIDE; P97441; -. DR Ensembl; ENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151. DR GeneID; 22784; -. DR KEGG; mmu:22784; -. DR CTD; 7781; -. DR MGI; MGI:1345280; Slc30a3. DR eggNOG; COG1230; -. DR HOGENOM; HOG000079023; -. DR HOVERGEN; HBG003345; -. DR InParanoid; P97441; -. DR KO; K14690; -. DR OMA; FKPQYKV; -. DR OrthoDB; EOG4VQ9PF; -. DR Reactome; REACT_94160; Transmembrane transport of small molecules. DR NextBio; 303355; -. DR ArrayExpress; P97441; -. DR Bgee; P97441; -. DR Genevestigator; P97441; -. DR GermOnline; ENSMUSG00000029151; Mus musculus. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0030672; C:synaptic vesicle membrane; IDA:MGI. DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro. DR GO; GO:0010312; P:detoxification of zinc ion; TAS:BHF-UCL. DR GO; GO:0051050; P:positive regulation of transport; IGI:MGI. DR GO; GO:0061088; P:regulation of sequestering of zinc ion; TAS:BHF-UCL. DR GO; GO:0032119; P:sequestering of zinc ion; TAS:BHF-UCL. DR GO; GO:0006829; P:zinc ion transport; TAS:BHF-UCL. DR InterPro; IPR002524; Cation_efflux. DR PANTHER; PTHR11562; PTHR11562; 1. DR Pfam; PF01545; Cation_efflux; 1. DR TIGRFAMs; TIGR01297; CDF; 1. PE 1: Evidence at protein level; KW Cell junction; Complete proteome; Cytoplasmic vesicle; Ion transport; KW Membrane; Phosphoprotein; Reference proteome; Synapse; Transmembrane; KW Transmembrane helix; Transport; Zinc; Zinc transport. FT CHAIN 1 388 Zinc transporter 3. FT /FTId=PRO_0000206097. FT TOPO_DOM 1 75 Cytoplasmic (Potential). FT TRANSMEM 76 96 Helical; (Potential). FT TOPO_DOM 97 105 Vacuolar (Potential). FT TRANSMEM 106 126 Helical; (Potential). FT TOPO_DOM 127 145 Cytoplasmic (Potential). FT TRANSMEM 146 166 Helical; (Potential). FT TOPO_DOM 167 177 Vacuolar (Potential). FT TRANSMEM 178 198 Helical; (Potential). FT TOPO_DOM 199 235 Cytoplasmic (Potential). FT TRANSMEM 236 256 Helical; (Potential). FT TOPO_DOM 257 263 Vacuolar (Potential). FT TRANSMEM 264 284 Helical; (Potential). FT TOPO_DOM 285 388 Cytoplasmic (Potential). FT MOD_RES 38 38 Phosphoserine. SQ SEQUENCE 388 AA; 41824 MW; 3CCDD0A37074EF41 CRC64; MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM AFHHCHKDPV PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL AIMTDAAHLL ADIGSMLASL FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NLLMAFVLHQ TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL GDLLQSFGVL AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPSQA //