ID ZNT3_MOUSE STANDARD; PRT; 388 AA. AC P97441; P97511; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE ZINC TRANSPORTER 3 (ZNT-3). GN SLC30A3 OR ZNT3. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. RN [1] RP SEQUENCE FROM N.A., AND CHARACTERIZATION. RC STRAIN=129; TISSUE=BRAIN; RX MEDLINE; 97121493. RA Palmiter R.D., Cole T.B., Quaife C.J., Findley S.D.; RT "ZnT-3, a putative transporter of zinc into synaptic vesicles."; RL Proc. Natl. Acad. Sci. U.S.A. 93:14934-14939(1996). CC -!- FUNCTION: INVOLVED IN ACCUMULATION OF ZINC IN SYNAPTIC VESICLES. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (TYPE II). CC LOCALIZED IN THE MEMBRANE OF SYNAPTIC VESICLES (PROBABLE). CC -!- TISSUE SPECIFICITY: BRAIN AND TESTIS. IN THE BRAIN, MOST ABUNDANT CC IN HIPPOCAMPUS AND CEREBRAL CORTEX. IN THE TESTIS, EXPRESSION IS CC RESTRICTED TO GERM CELLS AND IS HIGHEST IN PACHYTENE SPERMATOCYTES CC AND ROUND SPERMATIDS. CC -!- SIMILARITY: BELONGS TO THE SLC30A FAMILY OF TRANSPORTERS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U76007; AAB39731.1; -. DR EMBL; U76009; AAB39733.1; ALT_SEQ. DR EMBL; U76008; AAB39733.1; JOINED. DR MGD; MGI:107997; ZNT3. DR INTERPRO; IPR002524; -. DR PFAM; PF01545; Cation_efflux; 1. KW Zinc; Transport; Transmembrane; Multigene family. FT DOMAIN 1 75 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 76 96 POTENTIAL. FT DOMAIN 97 105 VACUOLAR (POTENTIAL). FT TRANSMEM 106 126 POTENTIAL. FT DOMAIN 127 145 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 146 166 POTENTIAL. FT DOMAIN 167 177 VACUOLAR (POTENTIAL). FT TRANSMEM 178 198 POTENTIAL. FT DOMAIN 199 235 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 236 256 POTENTIAL. FT DOMAIN 257 263 VACUOLAR (POTENTIAL). FT TRANSMEM 264 284 POTENTIAL. FT DOMAIN 285 388 CYTOPLASMIC (POTENTIAL). SQ SEQUENCE 388 AA; 41824 MW; 3CCDD0A37074EF41 CRC64; MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM AFHHCHKDPV PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL AIMTDAAHLL ADIGSMLASL FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NLLMAFVLHQ TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL GDLLQSFGVL AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPSQA //