ID OPRM_CAVPO Reviewed; 98 AA. AC P97266; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 02-SEP-2008, entry version 47. DE RecName: Full=Mu-type opioid receptor; DE AltName: Full=MOR-1; DE Flags: Fragment; GN Name=OPRM1; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricognathi; Caviidae; Cavia. OX NCBI_TaxID=10141; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Ronnekleiv O.K., Bosch M.A., Cunningham M.J., Wagner E.J., RA Grandy D.K., Kelly M.J.; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Inhibits neurotransmitter release by reducing calcium CC ion currents and increasing potassium ion conductance. Receptor CC for beta-endorphin. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U67928; AAB39617.1; -; Genomic_DNA. DR Ensembl; ENSCPOG00000008135; Cavia porcellus. DR HOVERGEN; P97266; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR000105; Mu_opioid_rcpt. DR InterPro; IPR001418; Opioid_rcpt. DR PANTHER; PTHR19264:SF229; Mu_opioid_rcpt; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00384; OPIOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; G-protein coupled receptor; Lipoprotein; Membrane; KW Palmitate; Phosphoprotein; Receptor; Transducer; Transmembrane. FT CHAIN <1 >98 Mu-type opioid receptor. FT /FTId=PRO_0000069971. FT TOPO_DOM <1 8 Cytoplasmic (Potential). FT TRANSMEM 9 26 2 (Potential). FT TOPO_DOM 27 48 Extracellular (Potential). FT TRANSMEM 49 68 3 (Potential). FT TOPO_DOM 69 >98 Cytoplasmic (Potential). FT NON_TER 1 1 FT NON_TER 98 98 SQ SEQUENCE 98 AA; 11161 MW; BEDB096924E0B9BE CRC64; YTKMKTATNI YIFNLALADA LATSTLPFQS VNYLMGTWPF GTILCKIVIS IDYYNMFTSI FTLCTMSVDR YIAVCHPVKA LDFRTPRNAK TVNVCNWI //