ID ARAP_BACSU STANDARD; PRT; 313 AA. AC P94529; O05094; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE L-arabinose transport system permease protein araP. GN ARAP OR BSU28740. OS Bacillus subtilis. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=1423; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=168; RX MEDLINE=97237725; PubMed=9084180; RA Sa-Nogueira I.M.G., Nogueira T.V., Soares S., de Lencastre H.; RT "The Bacillus subtilis L-arabinose (ara) operon: nucleotide sequence, RT genetic organization and expression."; RL Microbiology 143:957-969(1997). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=168; RX MEDLINE=97124191; PubMed=8969504; RA Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., RA Sanders J., Emmerson P.T., Harwood C.R.; RT "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus RT subtilis chromosome containing genes responsible for stress RT responses, the utilization of plant cell walls and primary RT metabolism."; RL Microbiology 142:3067-3078(1996). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=168; RX MEDLINE=98044033; PubMed=9384377; RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., RA Choi S.K., Codani J.J., Connerton I.F., Cummings N.J., Daniel R.A., RA Denizot F., Devine K.M., Dusterhoft A., Ehrlich S.D., Emmerson P.T., RA Entian K.D., Errington J., Fabret C., Ferrari E., Foulger D., RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., RA Ghim S.Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., RA Hilbert H., Holsappel S., Hosono S., Hullo M.F., Itaya M., Jones L., RA Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., RA Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., RA Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., RA Lee S.M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., RA Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., RA Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.H., RA Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., RA Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., RA Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., RA Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.S., Soldo B., RA Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., RA Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., RA Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., RA Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., RA Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., RA Yoshida K., Yoshikawa H.F., Zumstein E., Yoshikawa H., Danchin A.; RT "The complete genome sequence of the Gram-positive bacterium Bacillus RT subtilis."; RL Nature 390:249-256(1997). RN [4] RP TRANSCRIPTIONAL REGULATION. RX MEDLINE=99348379; PubMed=10417639; RA Mota L.J., Tavares P., Sa-Nogueira I.M.G.; RT "Mode of action of AraR, the key regulator of L-arabinose metabolism RT in Bacillus subtilis."; RL Mol. Microbiol. 33:476-489(1999). CC -!- FUNCTION: Part of the binding-protein-dependent transport system CC for L-arabinose. Probably responsible for the translocation of the CC substrate across the membrane. CC -!- SUBCELLULAR LOCATION: Integral membrane protein (Probable). CC -!- INDUCTION: Transcription is repressed by glucose and by the CC binding of araR to the operon promoter. L-arabinose acts as an CC inducer by inhibiting the binding of araR to the DNA, thus CC allowing expression of the gene. CC -!- SIMILARITY: BELONGS TO THE BINDING-PROTEIN-DEPENDENT TRANSPORT CC SYSTEM PERMEASE FAMILY. MALFG SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X89810; CAA61935.1; -. DR EMBL; Z75208; CAA99593.1; -. DR EMBL; Z99118; CAB14834.1; -. DR PIR; B69588; B69588. DR SubtiList; BG11911; araP. DR InterPro; IPR000515; BPD_transp. DR Pfam; PF00528; BPD_transp; 1. DR PROSITE; PS00402; BPD_TRANSP_INN_MEMBR; 1. KW Transport; Sugar transport; Transmembrane; Complete proteome. FT TRANSMEM 39 59 POTENTIAL. FT TRANSMEM 91 111 POTENTIAL. FT TRANSMEM 126 146 POTENTIAL. FT TRANSMEM 176 196 POTENTIAL. FT TRANSMEM 224 244 POTENTIAL. FT TRANSMEM 281 301 POTENTIAL. FT CONFLICT 186 186 R -> K (IN REF. 1). SQ SEQUENCE 313 AA; 35034 MW; F140CF2D7566F5A7 CRC64; MKPVKTGTVH PVPSAAKQSG WRDLFYSKKA APYLFTAPFV LSFLVFFLYP IISVFIMSFQ RILPGEVSFV GLSNYTALNN PTFYTALWNT LEYTFWTLIV LIPVPLLLAI FLNSKLVKFR NIFKSALFIP ALTSTIVAGI IFRLIFGEME TSLANSILLK LGFSPQNWMN NEHTGMFLMV LLASWRWMGI NILYFLAGLQ NVPKELYEAA DIDGANTMKK FLHITLPFLK PVTVYVLTIS IIGGFRMFEE SYVLWQNNSP GNIGLTLVGY LYQQGLAYNE MGYGAAIGIV LLIVILVVSL ISLKLSGSFK GEG //