ID HPPD_ARATH STANDARD; PRT; 445 AA. AC P93836; O04330; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (EC 1.13.11.27) (4HPPD) (HPD). GN HPD. OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Embryophyta; Tracheophyta; Spermatophyta; OC Magnoliophyta; eudicotyledons; core eudicots; Rosidae; eurosids II; OC Brassicales; Brassicaceae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=CV. WASSILEWSKIJA; RA Bartley G.E., Maxwell C.A., Wittenbach V.A., Scolnik P.A.; RT "Cloning of an Arabidopsis thaliana cDNA for p-hydroxyphenylpyruvate RT dioxygenase."; RL (In) Plant Gene Register PGR97-065. RN [2] RP SEQUENCE FROM N.A. RC STRAIN=CV. COLUMBIA; RA Norris S.R., Dellapenna D.; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC STRAIN=CV. COLUMBIA; RA Hsieh T.-F., Rodgers M., Matringe M.; RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: 4-HYDROXYPHENYLPYRUVATE + O(2) = CC HOMOGENTISATE + CO(2). CC -!- COFACTOR: IRON (BY SIMILARITY). CC -!- PATHWAY: CATABOLISM OF TYROSINE; SECOND STEP, CATABOLISM OF CC PHENYLALANINE; THIRD STEP. IN THE PATHWAY FOR BIOSYNTHESIS OF CC PRENYLQUINONES. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE 4HPPD FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U89267; AAB70025.1; -. DR EMBL; AF000228; AAB58404.1; -. DR EMBL; AF047834; AAC15697.1; -. DR INTERPRO; IPR002887; -. DR PFAM; PF01626; 4HPPD_C; 1. KW Oxidoreductase; Dioxygenase; Iron; Phenylalanine catabolism; KW Tyrosine catabolism. SQ SEQUENCE 445 AA; 48816 MW; FD0442F93556B3F5 CRC64; MGHQNAAVSE NQNHDDGAAS SPGFKLVGFS KFVRKNPKSD KFKVKRFHHI EFWCGDATNV ARRFSWGLGM RFSAKSDLST GNMVHASYLL TSGDLRFLFT APYSPSLSAG EIKPTTTASI PSFDHGSCRS FFSSHGLGVR AVAIEVEDAE SAFSISVANG AIPSSPPIVL NEAVTIAEVK LYGDVVLRYV SYKAEDTEKS EFLPGFERVE DASSFPLDYG IRRLDHAVGN VPELGPALTY VAGFTGFHQF AEFTADDVGT AESGLNSAVL ASNDEMVLLP INEPVHGTKR KSQIQTYLEH NEGAGLQHLA LMSEDIFRTL REMRKRSSIG GFDFMPSPPP TYYQNLKKRV GDVLSDDQIK ECEELGILVD RDDQGTLLQI FTKPLGDRPT IFIEIIQRVG CMMKDEEGKA YQSGGCGGFG KGNFSELFKS IEEYEKTLEA KQLVG //