ID COX3_ARATH Reviewed; 265 AA. AC P92514; Q8S8B5; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 04-MAY-2001, sequence version 2. DT 13-OCT-2009, entry version 83. DE RecName: Full=Cytochrome c oxidase subunit 3; DE EC=1.9.3.1; DE AltName: Full=Cytochrome c oxidase polypeptide III; GN Name=COX3; OrderedLocusNames=AtMg00730; OS Arabidopsis thaliana (Mouse-ear cress). OG Mitochondrion. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; OC rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX MEDLINE=97141919; PubMed=8988169; DOI=10.1038/ng0197-57; RA Unseld M., Marienfeld J.R., Brandt P., Brennicke A.; RT "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in RT 366,924 nucleotides."; RL Nat. Genet. 15:57-61(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07687). RC STRAIN=cv. Columbia; RX MEDLINE=20083487; PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., RA Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis RT thaliana."; RL Nature 402:761-768(1999). RN [3] RP RNA EDITING. RX MEDLINE=20079652; PubMed=10611383; DOI=10.1073/pnas.96.26.15324; RA Giege P., Brennicke A.; RT "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in RT ORFs."; RL Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999). CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- RNA EDITING: Modified_positions=38, 82, 86, 104, 105, 138, 141. CC -!- MISCELLANEOUS: A stretch of 270 kb of the mitochondrial genome is CC duplicated within the centromere of chromosome 2 resulting in the CC duplication of the gene. The expression of this duplicated gene CC (At2g07687) is not demonstrated. It is also probably not RNA CC edited and therefore differs in all the positions known to be CC edited. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y08501; CAA69818.3; ALT_SEQ; Genomic_DNA. DR EMBL; AC007143; AAM15412.1; ALT_SEQ; Genomic_DNA. DR IPI; IPI00532800; -. DR RefSeq; NP_085532.2; -. DR RefSeq; NP_178782.1; -. DR UniGene; At.47771; -. DR STRING; P92514; -. DR PRIDE; P92514; -. DR GeneID; 814601; -. DR GeneID; 815364; -. DR GenomeReviews; CT485783_GR; AT2G07687. DR GenomeReviews; Y08501_GR; ATMG00730. DR KEGG; ath:ArthMp065; -. DR TAIR; AtMg00730; -. DR BioCyc; MetaCyc:ATMG00730-MON; -. DR BRENDA; 1.9.3.1; 302. DR Genevestigator; P92514; -. DR GermOnline; ATMG00730; Arabidopsis thaliana. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0006123; P:mitochondrial electron transport, cytochrom...; IEA:InterPro. DR InterPro; IPR000298; Cyt_c_oxidase_su3. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR Gene3D; G3DSA:1.20.120.80; CytC_oxdse_III_a-bundle; 1. DR PANTHER; PTHR11403; CytC_oxdse_III; 1. DR Pfam; PF00510; COX3; 1. DR ProDom; PD000382; CytC_oxdse_III; 1. DR PROSITE; PS50253; COX3; 1. PE 2: Evidence at transcript level; KW Complete proteome; Membrane; Mitochondrion; KW Mitochondrion inner membrane; Oxidoreductase; RNA editing; KW Transmembrane. FT CHAIN 1 265 Cytochrome c oxidase subunit 3. FT /FTId=PRO_0000183737. FT TRANSMEM 41 61 Potential. FT TRANSMEM 85 105 Potential. FT TRANSMEM 137 157 Potential. FT TRANSMEM 162 182 Potential. FT TRANSMEM 200 220 Potential. FT TRANSMEM 245 265 Potential. SQ SEQUENCE 265 AA; 29961 MW; 753978DE1CAA13F1 CRC64; MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGARLLSLGL IFILYTMFVW WRDVLRESTL EGHHTKVVQL GLRYGFILFI VSEVMFFFAF FWAFFHSSLA PAVEIGGIWP PKGIEVLDPW EIPFLNTLIL LSSGAAVTWA HHAILAGKEK RAVYALVATV LLALVFTGFQ GMEYYQAPFT ISDSIYGSTF FLATGFHGFH VIIGTLFLII CGIRQYLGHL TKEHHVGFEA AAWYWHFVDV VWLFLFVSIY WWGGI //