ID COX3_ARATH Reviewed; 265 AA. AC P92514; A7KNG3; F4IMA5; Q8S8B5; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 04-MAY-2001, sequence version 2. DT 08-MAY-2019, entry version 147. DE RecName: Full=Cytochrome c oxidase subunit 3; DE EC=1.9.3.1; DE AltName: Full=Cytochrome c oxidase polypeptide III; GN Name=COX3; GN OrderedLocusNames=AtMg00730 {ECO:0000312|Araport:ATMG00730}; GN and GN OrderedLocusNames=At2g07687 {ECO:0000312|Araport:AT2G07687}; OS Arabidopsis thaliana (Mouse-ear cress). OG Mitochondrion. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. C24; RX PubMed=8988169; DOI=10.1038/ng0197-57; RA Unseld M., Marienfeld J.R., Brandt P., Brennicke A.; RT "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in RT 366,924 nucleotides."; RL Nat. Genet. 15:57-61(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. C24, cv. Columbia, and cv. Landsberg erecta; RX PubMed=21951689; DOI=10.1186/1741-7007-9-64; RA Davila J.I., Arrieta-Montiel M.P., Wamboldt Y., Cao J., Hagmann J., RA Shedge V., Xu Y.Z., Weigel D., Mackenzie S.A.; RT "Double-strand break repair processes drive evolution of the RT mitochondrial genome in Arabidopsis."; RL BMC Biol. 9:64-64(2011). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07687). RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., RA Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis RT thaliana."; RL Nature 402:761-768(1999). RN [4] RP GENOME REANNOTATION (AT2G07687). RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana RT reference genome."; RL Plant J. 89:789-804(2017). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-258, AND RNA EDITING. RC STRAIN=cv. Columbia, and cv. Landsberg erecta; TISSUE=Rosette leaf; RX PubMed=17565941; DOI=10.1534/genetics.107.073585; RA Bentolila S., Elliott L.E., Hanson M.R.; RT "Genetic architecture of mitochondrial editing in Arabidopsis RT thaliana."; RL Genetics 178:1693-1708(2008). RN [6] RP RNA EDITING. RX PubMed=10611383; DOI=10.1073/pnas.96.26.15324; RA Giege P., Brennicke A.; RT "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in RT ORFs."; RL Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999). CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex. CC -!- CATALYTIC ACTIVITY: CC Reaction=4 [Fe(II)cytochrome c] + 4 H(+) + O2 = 4 CC [Fe(III)cytochrome c] + 2 H2O; Xref=Rhea:RHEA:11436, Rhea:RHEA- CC COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, CC ChEBI:CHEBI:29034; EC=1.9.3.1; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; CC Multi-pass membrane protein {ECO:0000250}. CC -!- RNA EDITING: Modified_positions=38 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}, 82 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}, 86 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}, 104 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}, 105 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}, 138 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}, 141 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}; CC -!- MISCELLANEOUS: A stretch of 270 kb of the mitochondrial genome is CC duplicated within the centromere of chromosome 2 resulting in the CC duplication of the gene. The expression of this duplicated gene CC (At2g07687) is not demonstrated. It is also probably not RNA CC edited and therefore differs in all the positions known to be CC edited. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y08501; CAA69818.3; ALT_SEQ; Genomic_DNA. DR EMBL; JF729200; AEK01262.1; ALT_SEQ; Genomic_DNA. DR EMBL; JF729201; AEK01298.1; ALT_SEQ; Genomic_DNA. DR EMBL; JF729202; AEK01326.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC007143; AAM15412.1; ALT_SEQ; Genomic_DNA. DR EMBL; CP002685; AEC06078.1; ALT_SEQ; Genomic_DNA. DR EMBL; EF488906; ABS50618.1; -; mRNA. DR EMBL; EF488907; ABS50619.1; -; mRNA. DR RefSeq; NP_085532.2; NC_001284.2. DR RefSeq; NP_178782.1; NM_126741.2. DR SMR; P92514; -. DR STRING; 3702.ATMG00730.1; -. DR PaxDb; P92514; -. DR PRIDE; P92514; -. DR GeneID; 815364; -. DR KEGG; ath:ArthMp065; -. DR KEGG; ath:AT2G07687; -. DR Araport; AT2G07687; -. DR Araport; ATMG00730; -. DR eggNOG; KOG4664; Eukaryota. DR eggNOG; COG1845; LUCA. DR HOGENOM; HOG000264954; -. DR InParanoid; P92514; -. DR KO; K02262; -. DR OrthoDB; 1304563at2759; -. DR PhylomeDB; P92514; -. DR BioCyc; ARA:AT2G07687-MONOMER; -. DR BioCyc; ARA:ATMG00730-MONOMER; -. DR BioCyc; MetaCyc:ATMG00730-MONOMER; -. DR PRO; PR:P92514; -. DR Proteomes; UP000006548; Chromosome 2. DR Proteomes; UP000006548; Mitochondrion (cv. C24). DR ExpressionAtlas; P92514; baseline and differential. DR Genevisible; P92514; AT. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro. DR CDD; cd01665; Cyt_c_Oxidase_III; 1. DR Gene3D; 1.20.120.80; -; 1. DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3. DR InterPro; IPR033945; Cyt_c_oxase_su3_dom. DR InterPro; IPR000298; Cyt_c_oxidase-like_su3. DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR PANTHER; PTHR11403; PTHR11403; 1. DR Pfam; PF00510; COX3; 1. DR SUPFAM; SSF81452; SSF81452; 1. DR PROSITE; PS50253; COX3; 1. PE 2: Evidence at transcript level; KW Complete proteome; Membrane; Mitochondrion; KW Mitochondrion inner membrane; Oxidoreductase; Reference proteome; KW RNA editing; Transmembrane; Transmembrane helix. FT CHAIN 1 265 Cytochrome c oxidase subunit 3. FT /FTId=PRO_0000183737. FT TRANSMEM 41 61 Helical. {ECO:0000255}. FT TRANSMEM 85 105 Helical. {ECO:0000255}. FT TRANSMEM 137 157 Helical. {ECO:0000255}. FT TRANSMEM 162 182 Helical. {ECO:0000255}. FT TRANSMEM 200 220 Helical. {ECO:0000255}. FT TRANSMEM 245 265 Helical. {ECO:0000255}. SQ SEQUENCE 265 AA; 29961 MW; 753978DE1CAA13F1 CRC64; MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGARLLSLGL IFILYTMFVW WRDVLRESTL EGHHTKVVQL GLRYGFILFI VSEVMFFFAF FWAFFHSSLA PAVEIGGIWP PKGIEVLDPW EIPFLNTLIL LSSGAAVTWA HHAILAGKEK RAVYALVATV LLALVFTGFQ GMEYYQAPFT ISDSIYGSTF FLATGFHGFH VIIGTLFLII CGIRQYLGHL TKEHHVGFEA AAWYWHFVDV VWLFLFVSIY WWGGI //