ID ADA_DROME STANDARD; PRT; 940 AA. AC P91926; O01937; DT 15-DEC-1998 (Rel. 37, Created) DT 15-DEC-1998 (Rel. 37, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE ALPHA-ADAPTIN HOMOLOG. GN ALPHA-ADAPTIN. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=CANTON-S; RX MEDLINE; 97236497. RA Gonzalez-Gaitan M.A., Jaeckle H.; RT "Role of Drosophila alpha-adaptin in presynaptic vesicle recycling."; RL Cell 88:767-776(1997). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 97431776. RA Dornan S.C., Jackson A.P., Gay N.J.; RT "Alpha-adaptin, a marker for endocytosis, is expressed in complex RT patterns during Drosophila development."; RL Mol. Biol. Cell 8:1391-1403(1997). CC -!- FUNCTION: ADAPTINS ARE COMPONENTS OF THE ADAPTOR COMPLEXES CC WHICH LINK CLATHRIN TO RECEPTORS IN COATED VESICLES. CLATHRIN- CC ASSOCIATED PROTEIN COMPLEXES ARE BELIEVED TO INTERACT WITH THE CC CYTOPLASMIC TAILS OF MEMBRANE PROTEINS, LEADING TO THEIR SELECTION CC AND CONCENTRATION. ALPHA ADAPTIN IS A SUBUNIT OF THE PLASMA CC MEMBRANE ADAPTOR (BY SIMILARITY). CC -!- SUBUNIT: ASSEMBLY PROTEIN COMPLEX 2 (AP-2) IS A HETEROTETRAMER CC COMPOSED OF TWO LARGE CHAINS (ALPHA AND BETA), A MEDIUM CHAIN CC (AP50) AND A SMALL CHAIN (AP17). CC -!- SUBCELLULAR LOCATION: COMPONENT OF THE COAT SURROUNDING THE CC CYTOPLASMIC FACE OF COATED VESICLES IN THE PLASMA MEMBRANE (BY CC SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE ADAPTOR COMPLEXES LARGE SUBUNITS CC FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y11104; CAA71991.1; -. DR EMBL; Y13092; CAA73533.1; -. DR FLYBASE; FBgn0015567; alpha-Adaptin. DR INTERPRO; IPR002553; -. DR PFAM; PF01602; Adaptin_N; 1. KW Coated pits. FT CONFLICT 325 325 N -> E (IN REF. 2). FT CONFLICT 489 489 A -> P (IN REF. 2). FT CONFLICT 587 587 S -> N (IN REF. 2). FT CONFLICT 708 708 MISSING (IN REF. 2). FT CONFLICT 711 712 LF -> VS (IN REF. 2). FT CONFLICT 722 723 EM -> GK (IN REF. 2). FT CONFLICT 741 743 LFY -> FSN (IN REF. 2). FT CONFLICT 877 877 Q -> P (IN REF. 2). SQ SEQUENCE 940 AA; 105619 MW; F745045CD2C1D9C5 CRC64; MAPVRGDGMR GLAVFISDIR NCKSKEAEVK RINKELANIR SKFKGDKTLD GYQKKKYVCK LLFIFLLGHD IDFGHMEAVN LLSSNKYSEK QIGYLFISVL VNTNSDLIRL IIQSIKNDLQ SRNPVHVNLA LQCIANIGSR DMAESFSNEI PKLLVSGDTM DVVKQSAALC LLRLFRSSPD IIPGGEWTSR IIHLLNDQHM GVVTAATSLI DALVKRNPDE YKGCVNLAVS RLSRIVTASY TDLQDYTYYF VPAPWLSVKL LRLLQNYNPV TEEAGVRARL NETLETILNK AQEPPKSKKV QHSNAKNAVL FEAINLIIHS DSEPNLLVRA CNQLGQFLSN RETNLRYLAL ESMCHLATSE FSHEEVKKHQ EVVILSMKME KDVSVRQMAV DLLYAMCDRG NAEEIVQEML NYLETADYSI REEMVLKVAI LAEKYATDYT WYVDVILNLI RIAGDYVSEE VWYRVIQIVI NREEVQGYAA KTVFEALQAP ACHENMVKVG GYILGEFGNL IAGDSRSAPL VQFKLLHSKY HLCSPMTRAL LLSTYIKFIN LFPEIRTNIQ DVFRQHSNLR SADAELQQRA SEYLQLSIVA STDVLATVLE EMPSFPERES SILAVLKKKK PGRVPENEIR ESKSPAPLTS AAQNNALVNN SHSKLNNSNA NTDLLGLSTP PSNNIGSGSN SNSTLIDVLG DMYGSNSNNN SSAVYNTKKF LFKNNGVLFE NEMLQIGVKS EFRQNLGRLG LFYGNKTQVP LTNFNPVLQW SAEDALKLNV QMKVVEPTLE AGAQIQQLLT AECIEDYADA PTIEISFRYN GTQQKFSIKL PLSVNKFFEP TEMNAESFFA RWKNLSGEQQ RSQKVFKAAQ PLDLPGARNK LMGFGMQLLD QVDPNPDNMV CAGIIHTQSQ QVGCLMRLEP NKQAQMFRLT VRASKETVTR EICDLLTDQF //