ID PH4H_CAEEL STANDARD; PRT; 457 AA. AC P90925; DT 15-JUL-1998 (Rel. 36, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 25-JAN-2005 (Rel. 46, Last annotation update) DE Probable phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- DE monooxygenase) (Biogenic amine synthesis protein 2). GN Name=bas-2; ORFNames=K08F8.4; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: L-phenylalanine + tetrahydrobiopterin + O(2) = CC L-tyrosine + 4a-hydroxytetrahydrobiopterin. CC -!- COFACTOR: Ferrous ion (By similarity). CC -!- PATHWAY: Catabolism of phenylalanine; first (rate-limiting) step. CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid CC hydroxylase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z66497; CAA91286.1; -. DR PIR; T23494; T23494. DR HSSP; P04176; 1PHZ. DR IntAct; P90925; -. DR WormBase; WBGene00000240; bas-2. DR WormPep; K08F8.4; CE21050. DR InterPro; IPR001273; Aaa_hydroxylase. DR InterPro; IPR002912; ACT. DR InterPro; IPR005961; Phe4hydrxlaseTet. DR Pfam; PF01842; ACT; 1. DR Pfam; PF00351; Biopterin_H; 1. DR PRINTS; PR00372; FYWHYDRXLASE. DR ProDom; PD002559; Aaa_hydroxylase; 1. DR TIGRFAMs; TIGR01268; Phe4hydrox_tetr; 1. DR PROSITE; PS00367; BIOPTERIN_HYDROXYL; 1. KW Iron; Monooxygenase; Oxidoreductase; Phenylalanine catabolism. FT METAL 285 285 Iron (By similarity). FT METAL 290 290 Iron (By similarity). FT METAL 330 330 Iron (By similarity). SQ SEQUENCE 457 AA; 52129 MW; 68365836DFEC8D4F CRC64; MPPAGQDDLD FLKYAMESYV ADVNADIGKT TIVFTLREKA GALAETLKLF QAHDVNLSHI ESRPSKTHEG CYEVLVEFAE AEDHRKIEGV IEHFQQKAEK KVLVQDWNTK NKQNKDSVPW FPQKINDIDQ FANRILSYGA ELDADHPGFK DMTYRERRKF FADIAFNFKH GDKIPTITYT DEEIATWRTV YNELTVMYPK NACQEFNYIF PLLQQNCGFG PDRIPQLQDV SDFLKDCTGY TIRPVAGLLS SRDFLAGLAF RVFHSTQYIR HHSAPKYTPE PDICHELLGH VPLFADVEFA QFSQEIGLAS LGAPDDVIEK LATLYWFTIE FGICQQDGEK KAYGAGLLSS FGELQYALSD KPEVVDFDPA VCCVTKYPIT EYQPKYFLAE SFASAKNKLK SWAATINRPF QIRYNAYTQR VEILDKVAAL QRLARDIRSD ISTLEEALGK VNNLKMK //