ID PH4H_CAEEL STANDARD; PRT; 466 AA. AC P90925; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE PUTATIVE PHENYLALANINE-4-HYDROXYLASE (EC 1.14.16.1) (PAH) (PHE-4- DE MONOOXYGENASE). GN K08F8.4. OS CAENORHABDITIS ELEGANS. OC EUKARYOTA; METAZOA; ACOELOMATES; NEMATODA; SECERNENTEA; RHABDITIDA. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BRISTOL N2; RA SMYE R.; RL SUBMITTED (NOV-1996) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- CATALYTIC ACTIVITY: L-PHENYLALANINE + TETRAHYDROBIOPTERIN + CC O(2) = L-TYROSINE + DIHYDROBIOPTERIN + H(2)O. CC -!- COFACTOR: THIS ENZYME REQUIRES A FERROUS ION (BY SIMILARITY). CC -!- PATHWAY: RATE-LIMITING STEP IN PHENYLALANINE CATABOLISM. CC -!- SIMILARITY: BELONGS TO THE BIOPTERIN-DEPENDENT AROMATIC AMINO ACID CC HYDROXYLASES FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z66497; E284944; -. DR WORMPEP; K08F8.4; CE11934. DR PROSITE; PS00367; BIOPTERIN_HYDROXYL; 1. KW HYPOTHETICAL PROTEIN; OXIDOREDUCTASE; MONOOXYGENASE; KW PHENYLALANINE CATABOLISM; IRON. FT METAL 285 285 IRON (BY SIMILARITY). FT METAL 290 290 IRON (BY SIMILARITY). FT METAL 330 330 IRON (BY SIMILARITY). SQ SEQUENCE 466 AA; 53239 MW; 13553736 CRC32; MPPAGQDDLD FLKYAMESYV ADVNADIGKT TIVFTLREKA GALAETLKLF QAHDVNLSHI ESRPSKTHEG CYEVLVEFAE AEDHRKIEGV IEHFQQKAEK KVLVQDWNTK NKQNKDSVPW FPQKINDIDQ FANRILSYGA ELDADHPGFK DMTYRERRKF FADIAFNFKH GDKIPTITYT DEEIATWRTV YNELTVMYPK NACQEFNYIF PLLQQNCGFG PDRIPQLQDV SDFLKDCTGY TIRPVAGLLS SRDFLAGLAF RVFHSTQYIR HHSAPKYTPE PDICHELLGH VPLFADVEFA QFSQEIGLAS LGAPDDVIEK LATLYWFTIE FGICQQDGEK KAYGAGLLSS FGELQYALSD KPEVVDFDPA VCCVTKYPIT EYQPKYFLAE SFASAKNKLN FNCNLDNFRS WAATINRPFQ IRYNAYTQRV EILDKVAALQ RLARDIRSDI STLEEALGKV NNLKMK //