ID   WD66_PHYPO              Reviewed;         601 AA.
AC   P90587;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-OCT-2024, entry version 82.
DE   RecName: Full=66 kDa stress protein;
DE   AltName: Full=p66;
OS   Physarum polycephalum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Myxogastria;
OC   Myxogastromycetidae; Physariida; Physaraceae; Physarum.
OX   NCBI_TaxID=5791;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9685722; DOI=10.1093/oxfordjournals.jbchem.a022115;
RA   Matsumoto S., Ogawa M., Kasakura T., Shimada Y., Mitsui M., Maruya M.,
RA   Isohata M., Yahara I., Murakami-Murofushi K.;
RT   "A novel 66-kDa stress protein, p66, associated with the process of cyst
RT   formation of Physarum polycephalum is a Physarum homologue of a yeast
RT   actin-interacting protein, AIP1.";
RL   J. Biochem. 124:326-331(1998).
CC   -!- FUNCTION: Associated with the process of cyst formation.
CC   -!- SIMILARITY: Belongs to the WD repeat AIP1 family. {ECO:0000305}.
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DR   EMBL; U86011; AAC26321.1; -; mRNA.
DR   PIR; JE0238; JE0238.
DR   AlphaFoldDB; P90587; -.
DR   SMR; P90587; -.
DR   GO; GO:0030864; C:cortical actin cytoskeleton; IEA:TreeGrafter.
DR   GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter.
DR   GO; GO:0030042; P:actin filament depolymerization; IEA:TreeGrafter.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19856:SF0; WD REPEAT-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR19856; WD-REPEATCONTAINING PROTEIN WDR1; 1.
DR   Pfam; PF00400; WD40; 7.
DR   SMART; SM00320; WD40; 10.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Repeat; WD repeat.
FT   CHAIN           1..601
FT                   /note="66 kDa stress protein"
FT                   /id="PRO_0000051334"
FT   REPEAT          56..95
FT                   /note="WD 1"
FT   REPEAT          100..143
FT                   /note="WD 2"
FT   REPEAT          145..184
FT                   /note="WD 3"
FT   REPEAT          187..226
FT                   /note="WD 4"
FT   REPEAT          233..272
FT                   /note="WD 5"
FT   REPEAT          318..357
FT                   /note="WD 6"
FT   REPEAT          435..478
FT                   /note="WD 7"
FT   REPEAT          483..522
FT                   /note="WD 8"
FT   REPEAT          526..565
FT                   /note="WD 9"
FT   REPEAT          569..600
FT                   /note="WD 10"
SQ   SEQUENCE   601 AA;  64322 MW;  F691217D838F747A CRC64;
     MSFALKTIYS PSPATTRGKP VVLGGDPKGN NFLYTCGNAV IIRNIKNPNQ ADIYYEHAQP
     ATVAKYAPSG FYIASGDLSG TLRIWDTTQL EHPLKIELKV LSGPIADIAW SADSQRLVVV
     GDGKERFGAA ILWDSGASVG EITGHSKAIA SCDFKATRPF RVITGAEDFQ ANWFEGPPFK
     FKHAFKEHTR FLTCVRFSPD GEKVLTVGLD KKGFILDGKT GEKVGALAGG ADAHALGIYS
     CSWSPDSKKV LTVSADKSAK IWDDKGTLLT TFAFEGGVES QLLGSLWQGD TLLAVNLNGD
     IFSLDQNNPK TPARTLKGHN KLVTSLAFDT ASKALYSGSY DGVILQWNLE TGIAVPIAGT
     GHTSSVTQAV VQGNKLVSVS VDDTTRFTPL NPPQYAAQGA KLDSQPQSVA VAQGKDIAVV
     VTLNSVVVLQ GEKVASTTAV KYQPTVVRVS VDGSEVAVGA KDNSIHIYSL SGTTLSEQAV
     LSGHRGFLTA IAYSPDGKHF ASADQNRDIF VWDKASRKIK VEGWVYHNAR VTSLAWNSNS
     NNIVTGSLDS HVYVWSVSEP SKHIAIKNAH RGGVNAVLWV DEHTVASAGL DCSIKTWTIK
     N
//