ID PRVB1_MERHU Reviewed; 108 AA. AC P86764; DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot. DT 05-OCT-2010, sequence version 1. DT 02-NOV-2010, entry version 2. DE RecName: Full=Parvalbumin beta 1; OS Merluccius hubbsi (Argentine hake) (Merluccius gayi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Paracanthopterygii; Gadiformes; Merlucciidae; OC Merlucciinae; Merluccius. OX NCBI_TaxID=89949; RN [1] RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND ACETYLATION AT ALA-1. RC TISSUE=Muscle; RX PubMed=20586483; DOI=10.1021/pr100163e; RA Carrera M., Canas B., Vazquez J., Gallardo J.M.; RT "Extensive de novo sequencing of new parvalbumin isoforms using a RT novel combination of bottom-up proteomics, accurate molecular mass RT measurement by FTICR-MS, and selected MS/MS ion monitoring."; RL J. Proteome Res. 9:4393-4406(2010). CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in CC relaxation after contraction. It binds two calcium ions (By CC similarity). CC -!- MASS SPECTROMETRY: Mass=11329.748; Mass_error=0.006; CC Method=Electrospray; Range=1-108; Source=PubMed:20586483; CC -!- MISCELLANEOUS: Is regarded as an important allergen. CC -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: CC 4.57, its MW is: 11.30 kDa. CC -!- SIMILARITY: Belongs to the parvalbumin family. CC -!- SIMILARITY: Contains 2 EF-hand domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR InterPro; IPR011992; EF-hand-like_dom. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR018249; EF_HAND_2. DR InterPro; IPR002048; EF_hand_Ca-bd. DR InterPro; IPR008080; Parvalbumin. DR Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1. DR PRINTS; PR01697; PARVALBUMIN. DR SMART; SM00054; EFh; 2. DR PROSITE; PS00018; EF_HAND_1; 2. DR PROSITE; PS50222; EF_HAND_2; 2. PE 1: Evidence at protein level; KW Acetylation; Allergen; Calcium; Direct protein sequencing; KW Metal-binding; Muscle protein; Repeat. FT CHAIN 1 108 Parvalbumin beta 1. FT /FTId=PRO_0000399422. FT DOMAIN 38 73 EF-hand 1. FT DOMAIN 77 108 EF-hand 2. FT CA_BIND 51 62 1 (Potential). FT CA_BIND 90 101 2 (Potential). FT MOD_RES 1 1 N-acetylalanine. FT UNSURE 5 5 I or L. FT UNSURE 6 6 L or I. FT UNSURE 11 11 I or L. FT UNSURE 15 15 L or I. FT UNSURE 19 19 K or Q. FT UNSURE 25 25 K or Q. FT UNSURE 32 32 K or Q. FT UNSURE 33 33 I or L. FT UNSURE 35 35 L or I. FT UNSURE 36 36 K or Q. FT UNSURE 38 38 K or Q. FT UNSURE 43 43 I or L. FT UNSURE 44 44 K or Q. FT UNSURE 45 45 K or Q. FT UNSURE 49 49 I or L. FT UNSURE 50 50 I or L. FT UNSURE 52 52 Q or K. FT UNSURE 54 54 K or Q. FT UNSURE 63 63 L or I. FT UNSURE 64 64 K or Q. FT UNSURE 65 65 L or I. FT UNSURE 67 67 L or I. FT UNSURE 68 68 Q or K. FT UNSURE 77 77 L or I. FT UNSURE 86 86 L or I. FT UNSURE 87 87 K or Q. FT UNSURE 96 96 K or Q. FT UNSURE 97 97 I or L. FT UNSURE 107 107 K or Q. SQ SEQUENCE 108 AA; 11295 MW; 94606DBCF3D93E34 CRC64; AFAGILADAD ITAALAACKA EGTFKHGEFF TKIGLKGKSA ADIKKVFGII DQDKSDFVEE DELKLFLQNF SAGARALTDA ETATFLKAGD SDGDGKIGVD EFAAMVKG //