ID KTX81_MESEU Reviewed; 29 AA. AC P86400; DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot. DT 30-NOV-2010, sequence version 1. DT 29-OCT-2014, entry version 15. DE RecName: Full=Toxin MeuKTx-1; OS Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; OC Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus. OX NCBI_TaxID=34648; RN [1] {ECO:0000305} RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, RP AND MASS SPECTROMETRY. RC TISSUE=Venom {ECO:0000269|Ref.1}; RA Zhu S.Y., Gao B.; RT "Characterization of a potassium channel toxin from the scorpion RT Mesobuthus eupeus venom."; RL Submitted (NOV-2009) to UniProtKB. CC -!- FUNCTION: Inhibits Kv1.1/KCNA1, Kv3/KCNC and Shaker potassium CC channels. {ECO:0000269|Ref.1}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC {ECO:0000269|Ref.1}. CC -!- MASS SPECTROMETRY: Mass=3251; Method=MALDI; Range=1-29; CC Evidence={ECO:0000269|Ref.1}; CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. CC Potassium channel inhibitor family. Alpha-KTx 8 subfamily. CC {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:InterPro. DR GO; GO:0009405; P:pathogenesis; IEA:InterPro. DR InterPro; IPR003614; Scorpion_toxin-like. DR InterPro; IPR008911; Toxin_6. DR Pfam; PF05453; Toxin_6; 1. DR SUPFAM; SSF57095; SSF57095; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; KW Ion channel impairing toxin; Neurotoxin; KW Potassium channel impairing toxin; Secreted; Toxin; KW Voltage-gated potassium channel impairing toxin. FT PEPTIDE 1 29 Toxin MeuKTx-1. FT /FTId=PRO_0000401115. FT DISULFID 3 19 {ECO:0000250|UniProtKB:Q9U8D2}. FT DISULFID 6 24 {ECO:0000250|UniProtKB:Q9U8D2}. FT DISULFID 10 26 {ECO:0000250|UniProtKB:Q9U8D2}. SQ SEQUENCE 29 AA; 3256 MW; 34351B0DF96DDA94 CRC64; VSCEDCPEHC ATKDQRAKCD NDKCVCEPK //