ID VIP_MACMU Reviewed; 28 AA. AC P84488; DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot. DT 29-MAR-2005, sequence version 1. DT 29-MAY-2024, entry version 67. DE RecName: Full=Vasoactive intestinal peptide; DE Short=VIP; DE AltName: Full=Vasoactive intestinal polypeptide; GN Name=VIP; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP PROTEIN SEQUENCE. RX PubMed=2003150; DOI=10.1016/0167-0115(91)90005-2; RA Yu J.-H., Xin Y., Eng J., Yalow R.S.; RT "Rhesus monkey gastroenteropancreatic hormones: relationship to human RT sequences."; RL Regul. Pept. 32:39-45(1991). CC -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure, CC stimulates myocardial contractility, increases glycogenolysis and CC relaxes the smooth muscle of trachea, stomach and gall bladder. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; B60071; B60071. DR AlphaFoldDB; P84488; -. DR SMR; P84488; -. DR eggNOG; ENOG502QVTA; Eukaryota. DR HOGENOM; CLU_133877_1_0_1; -. DR InParanoid; P84488; -. DR Proteomes; UP000006718; Unassembled WGS sequence. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter. DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro. DR GO; GO:0051428; F:peptide hormone receptor binding; IEA:TreeGrafter. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProt. DR GO; GO:0048242; P:epinephrine secretion; IEA:TreeGrafter. DR GO; GO:0007611; P:learning or memory; IEA:TreeGrafter. DR GO; GO:0048255; P:mRNA stabilization; ISS:AgBase. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:TreeGrafter. DR GO; GO:0043267; P:negative regulation of potassium ion transport; IEA:TreeGrafter. DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:TreeGrafter. DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:TreeGrafter. DR GO; GO:0032812; P:positive regulation of epinephrine secretion; IEA:TreeGrafter. DR GO; GO:0060406; P:positive regulation of penile erection; IEA:TreeGrafter. DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:TreeGrafter. DR GO; GO:0070459; P:prolactin secretion; ISS:AgBase. DR GO; GO:0032880; P:regulation of protein localization; IEA:TreeGrafter. DR Gene3D; 6.10.250.590; -; 1. DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP. DR InterPro; IPR046963; VIP/GHRH-like. DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1. DR PANTHER; PTHR11213:SF5; VIP PEPTIDES; 1. DR Pfam; PF00123; Hormone_2; 1. DR SMART; SM00070; GLUCA; 1. DR PROSITE; PS00260; GLUCAGON; 1. PE 1: Evidence at protein level; KW Amidation; Direct protein sequencing; Hormone; Reference proteome; KW Secreted. FT PEPTIDE 1..28 FT /note="Vasoactive intestinal peptide" FT /id="PRO_0000043942" FT MOD_RES 28 FT /note="Asparagine amide" FT /evidence="ECO:0000250|UniProtKB:P01282" SQ SEQUENCE 28 AA; 3327 MW; EF313FB573FF6F3F CRC64; HSDAVFTDNY TRLRKQMAVK KYLNSILN //