ID TXD2_PARLU STANDARD; PRT; 37 AA. AC P83257; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Delta-palutoxin IT2 (Delta-paluIT2). OS Paracoelotes luctuosus (Spider). OC Eukaryota; Metazoa; Arthropoda; Chelicerata; Arachnida; Araneae; OC Araneomorphae; Entelegynae; Amaurobiidae; Paracoelotes. OX NCBI_TaxID=185217; RN [1] RP SEQUENCE, FUNCTION, AND MASS SPECTROMETRY. RC TISSUE=Venom; RX MEDLINE=20428467; PubMed=10971590; RA Corzo G., Escoubas P., Stankiewicz M., Pelhate M., Kristensen C.P., RA Nakajima T.; RT "Isolation, synthesis and pharmacological characterization of delta- RT palutoxins IT, novel insecticidal toxins from the spider Paracoelotes RT luctuosus (Amaurobiidae)."; RL Eur. J. Biochem. 267:5783-5795(2000). CC -!- FUNCTION: Potent activity against S.litura larvae. CC -!- FUNCTION: Binds to sodium channels and inhibits the inactivation CC of the activated channels. This toxin is active only on insects CC (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- MASS SPECTROMETRY: MW=4114.6; METHOD=MALDI; RANGE=1-37; CC NOTE=Ref.1. CC -!- SIMILARITY: Belongs to the mu-agatoxin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR HSSP; P11057; 1EIT. DR GO; GO:0005576; C:extracellular; NAS. DR GO; GO:0019871; F:sodium channel inhibitor activity; IDA. DR GO; GO:0009405; P:pathogenesis; IDA. DR InterPro; IPR009243; Toxin_7. DR Pfam; PF05980; Toxin_7; 1. KW Amidation; Direct protein sequencing; Ionic channel inhibitor; KW Neurotoxin; Sodium channel inhibitor; Toxin. FT DISULFID 2 18 By similarity. FT DISULFID 9 23 By similarity. FT DISULFID 17 33 By similarity. FT DISULFID 25 31 By similarity. FT MOD_RES 37 37 Serine amide. SQ SEQUENCE 37 AA; 4124 MW; 861E12C2EB547716 CRC64; ACVGDGQRCA SWSGPYCCDG YYCSCRSMPY CRCRNNS //