ID PLS_HALLA Reviewed; 84 AA. AC P82595; DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot. DT 26-SEP-2001, sequence version 2. DT 03-MAY-2023, entry version 65. DE RecName: Full=Perlustrin; OS Haliotis laevigata (Smooth Australian abalone). OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; OC Vetigastropoda; Lepetellida; Haliotoidea; Haliotidae; Haliotis. OX NCBI_TaxID=36097; RN [1] RP PROTEIN SEQUENCE, AND MASS SPECTROMETRY. RC TISSUE=Shell; RX PubMed=11444832; DOI=10.1006/bbrc.2001.5170; RA Weiss I.M., Goehring W., Fritz M., Mann K.; RT "Perlustrin, a Haliotis laevigata (abalone) nacre protein, is homologous to RT the insulin-like growth factor binding protein N-terminal module of RT vertebrates."; RL Biochem. Biophys. Res. Commun. 285:244-249(2001). RN [2] RP PROTEIN SEQUENCE OF 1-33. RC TISSUE=Shell; RX PubMed=10623567; DOI=10.1006/bbrc.1999.1907; RA Weiss I.M., Kaufmann S., Mann K., Fritz M.; RT "Purification and characterization of perlucin and perlustrin, two new RT proteins from the shell of the mollusc Haliotis laevigata."; RL Biochem. Biophys. Res. Commun. 267:17-21(2000). CC -!- FUNCTION: Binds human IGF-I and IGF-II and bovine insulin. CC -!- TISSUE SPECIFICITY: Shell. CC -!- MASS SPECTROMETRY: Mass=9325.8; Method=Electrospray; CC Evidence={ECO:0000269|PubMed:11444832}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; P82595; -. DR SMR; P82595; -. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW. DR Gene3D; 4.10.40.20; -; 1. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR000867; IGFBP-like. DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS. DR Pfam; PF00219; IGFBP; 1. DR SMART; SM00121; IB; 1. DR SUPFAM; SSF57184; Growth factor receptor domain; 1. DR PROSITE; PS00222; IGFBP_N_1; 1. DR PROSITE; PS51323; IGFBP_N_2; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Growth factor binding. FT CHAIN 1..84 FT /note="Perlustrin" FT /id="PRO_0000152777" FT DOMAIN 1..82 FT /note="IGFBP N-terminal" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 3..28 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 6..30 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 11..31 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 18..34 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 42..55 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 49..79 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" SQ SEQUENCE 84 AA; 9338 MW; 42B47741B9101A5B CRC64; LSCASCENAA CPAIGLPCKP SEYVYTPCGC CPQCPLELGQ PCGSFTQRCQ FDLWCLRRKG NKIEAYKYVP WHLDFKGVCA RVDV //