ID WTX1F_NEOGO Reviewed; 20 AA. AC P82428; DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot. DT 26-SEP-2001, sequence version 1. DT 27-MAR-2024, entry version 65. DE RecName: Full=M-poneritoxin-Ng1f {ECO:0000303|PubMed:26805882}; DE Short=M-PONTX-Ng1f {ECO:0000303|PubMed:26805882}; DE AltName: Full=Poneratoxin {ECO:0000305}; DE AltName: Full=Ponericin-W6 {ECO:0000303|PubMed:11279030}; OS Neoponera goeldii (Ponerine ant) (Pachycondyla goeldii). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea; OC Formicidae; Ponerinae; Ponerini; Neoponera. OX NCBI_TaxID=3057131; RN [1] RP PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AMIDATION AT LYS-20, AND RP SUBCELLULAR LOCATION. RC TISSUE=Venom; RX PubMed=11279030; DOI=10.1074/jbc.m100216200; RA Orivel J., Redeker V., Le Caer J.-P., Krier F., Revol-Junelles A.-M., RA Longeon A., Chafotte A., Dejean A., Rossier J.; RT "Ponericins, new antibacterial and insecticidal peptides from the venom of RT the ant Pachycondyla goeldii."; RL J. Biol. Chem. 276:17823-17829(2001). RN [2] RP REVIEW, AND NOMENCLATURE. RX PubMed=26805882; DOI=10.3390/toxins8010030; RA Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M., RA Dejean A.; RT "The biochemical toxin arsenal from ant venoms."; RL Toxins 8:1-28(2016). CC -!- FUNCTION: Has activity against Gram-positive bacteria. Has insecticidal CC and hemolytic activities. May act by disrupting the integrity of the CC bacterial cell membrane. {ECO:0000269|PubMed:11279030}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11279030}. Target CC cell membrane {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC {ECO:0000305|PubMed:11279030}. CC -!- MASS SPECTROMETRY: Mass=2029.40; Method=MALDI; CC Evidence={ECO:0000269|PubMed:11279030}; CC -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP) CC superfamily. Medium-length antimicrobial peptide (group 3) family. CC Ponericin-W subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; P82428; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-KW. DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW. PE 1: Evidence at protein level; KW Amidation; Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; KW Hemolysis; Membrane; Secreted; Target cell membrane; Target membrane; KW Toxin. FT PEPTIDE 1..20 FT /note="M-poneritoxin-Ng1f" FT /evidence="ECO:0000269|PubMed:11279030" FT /id="PRO_0000044199" FT MOD_RES 20 FT /note="Lysine amide" FT /evidence="ECO:0000269|PubMed:11279030" SQ SEQUENCE 20 AA; 2031 MW; 5241E1528A9A98EB CRC64; FIGTALGIAS AIPAIVKLFK //