ID OR33A_DROME Reviewed; 378 AA. AC P81914; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1999, sequence version 1. DT 15-FEB-2017, entry version 120. DE RecName: Full=Odorant receptor 33a; GN Name=Or33a; Synonyms=AN3, DOR33B.1, dor73, Or33B.1; ORFNames=CG16960; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10458908; DOI=10.1006/geno.1999.5894; RA Gao Q., Chess A.; RT "Identification of candidate Drosophila olfactory receptors from RT genomic DNA sequence."; RL Genomics 60:31-39(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP IDENTIFICATION, AND TISSUE SPECIFICITY. RX PubMed=10069338; DOI=10.1016/S0896-6273(00)81093-4; RA Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.; RT "A novel family of divergent seven-transmembrane proteins: candidate RT odorant receptors in Drosophila."; RL Neuron 22:327-338(1999). RN [5] RP IDENTIFICATION, AND TISSUE SPECIFICITY. RC STRAIN=Oregon-R; TISSUE=Antenna; RX PubMed=10089887; DOI=10.1016/S0092-8674(00)80582-6; RA Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.; RT "A spatial map of olfactory receptor expression in the Drosophila RT antenna."; RL Cell 96:725-736(1999). RN [6] RP TISSUE SPECIFICITY. RX PubMed=10943836; DOI=10.1016/S0092-8674(00)00021-0; RA Vosshall L.B., Wong A.M., Axel R.; RT "An olfactory sensory map in the fly brain."; RL Cell 102:147-159(2000). CC -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance CC behavior, depending on its substrates. The odorant receptor CC repertoire encodes a large collection of odor stimuli that vary CC widely in identity, intensity, and duration. May form a complex CC with Orco to form odorant-sensing units, providing sensitive and CC prolonged odorant signaling and calcium permeability (By CC similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with Orco. Complexes exist early in the CC endomembrane system in olfactory sensory neurons (OSNs), coupling CC these complexes to the conserved ciliary trafficking pathway (By CC similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass CC membrane protein {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed in 1-2 cells on the distal edge of CC the antenna but not the maxillary palp. CC {ECO:0000269|PubMed:10069338, ECO:0000269|PubMed:10089887, CC ECO:0000269|PubMed:10943836}. CC -!- MISCELLANEOUS: The atypical heteromeric and topological design of CC the odorant receptors appears to be an insect-specific solution CC for odor recognition, making the OR/Orco complex an attractive CC target for the development of highly selective insect repellents CC to disrupt olfactory-mediated host-seeking behaviors of insect CC disease vectors. Odor-evoked OR currents are independent of known CC G-protein-coupled second messenger pathways. CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF53131.1; -; Genomic_DNA. DR RefSeq; NP_523553.1; NM_078829.1. DR UniGene; Dm.26795; -. DR ProteinModelPortal; P81914; -. DR BioGrid; 60654; 2. DR DIP; DIP-22508N; -. DR MINT; MINT-1644139; -. DR STRING; 7227.FBpp0079862; -. DR PaxDb; P81914; -. DR PRIDE; P81914; -. DR EnsemblMetazoa; FBtr0080278; FBpp0079862; FBgn0026392. DR GeneID; 34601; -. DR KEGG; dme:Dmel_CG16960; -. DR CTD; 34601; -. DR FlyBase; FBgn0026392; Or33a. DR eggNOG; ENOG410JDA5; Eukaryota. DR eggNOG; ENOG410YKTV; LUCA. DR GeneTree; ENSGT00540000073151; -. DR InParanoid; P81914; -. DR KO; K08471; -. DR OMA; FFCFRWK; -. DR OrthoDB; EOG091909JI; -. DR PhylomeDB; P81914; -. DR GenomeRNAi; 34601; -. DR PRO; PR:P81914; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0026392; -. DR Genevisible; P81914; DM. DR GO; GO:0032590; C:dendrite membrane; ISS:FlyBase. DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005549; F:odorant binding; ISS:FlyBase. DR GO; GO:0004984; F:olfactory receptor activity; NAS:UniProtKB. DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase. DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB. DR InterPro; IPR004117; 7tm6_olfct_rcpt. DR PANTHER; PTHR21137; PTHR21137; 1. DR Pfam; PF02949; 7tm_6; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Membrane; Olfaction; Receptor; KW Reference proteome; Sensory transduction; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1 378 Odorant receptor 33a. FT /FTId=PRO_0000174238. FT TOPO_DOM 1 33 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 34 54 Helical; Name=1. {ECO:0000255}. FT TOPO_DOM 55 62 Extracellular. {ECO:0000255}. FT TRANSMEM 63 83 Helical; Name=2. {ECO:0000255}. FT TOPO_DOM 84 127 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 128 148 Helical; Name=3. {ECO:0000255}. FT TOPO_DOM 149 163 Extracellular. {ECO:0000255}. FT TRANSMEM 164 184 Helical; Name=4. {ECO:0000255}. FT TOPO_DOM 185 254 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 255 275 Helical; Name=5. {ECO:0000255}. FT TOPO_DOM 276 285 Extracellular. {ECO:0000255}. FT TRANSMEM 286 306 Helical; Name=6. {ECO:0000255}. FT TOPO_DOM 307 355 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 356 376 Helical; Name=7. {ECO:0000255}. FT TOPO_DOM 377 378 Extracellular. {ECO:0000255}. SQ SEQUENCE 378 AA; 43892 MW; D5BE000865EBCA21 CRC64; MDSRRKVRSE NLYKTYWLYW RLLGVEGDYP FRRLVDFTIT SFITILFPVH LILGMYKKPQ IQVFRSLHFT SECLFCSYKF FCFRWKLKEI KTIEGLLQDL DSRVESEEER NYFNQNPSRV ARMLSKSYLV AAISAIITAT VAGLFSTGRN LMYLGWFPYD FQATAAIYWI SFSYQAIGSS LLILENLAND SYPPITFCVV SGHVRLLIMR LSRIGHDVKL SSSENTRKLI EGIQDHRKLM KIIRLLRSTL HLSQLGQFLS SGINISITLI NILFFAENNF AMLYYAVFFA AMLIELFPSC YYGILMTMEF DKLPYAIFSS NWLKMDKRYN RSLIILMQLT LVPVNIKAGG IVGIDMSAFF ATVRMAYSFY TLALSFRV //