ID   TXM1_DENAN     STANDARD;      PRT;    66 AA.
AC   P81030;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   29-MAR-2004 (Rel. 43, Last annotation update)
DE   Muscarinic toxin 1 (MT1) (MTx1).
OS   Dendroaspis angusticeps (Eastern green mamba).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea;
OC   Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8618;
RN   [1]
RP   SEQUENCE.
RX   MEDLINE=94205875; PubMed=8154745;
RA   Karlsson E., Jolkkonen M., Satyapan N., Adem A., Kumlin E.,
RA   Hellman U., Wernstedt C.;
RT   "Protein toxins that bind to muscarinic acetylcholine receptors.";
RL   Ann. N. Y. Acad. Sci. 710:153-161(1994).
RN   [2]
RP   SEQUENCE.
RX   MEDLINE=96018124; PubMed=7570626;
RA   Jolkkonen M., Adem A., Hellman U., Wernstedt C., Karlsson E.;
RT   "A snake toxin against muscarinic acetylcholine receptors: amino acid
RT   sequence, subtype specificity and effect on guinea-pig ileum.";
RL   Toxicon 33:399-410(1995).
RN   [3]
RP   FUNCTION.
RX   PubMed=7778123;
RA   Kornisiuk E., Jerusalinsky D., Cervenansky C., Harvey A.L.;
RT   "Binding of muscarinic toxins MTx1 and MTx2 from the venom of the
RT   green mamba Dendroaspis angusticeps to cloned human muscarinic
RT   cholinoceptors.";
RL   Toxicon 33:11-18(1995).
CC   -!- FUNCTION: Binds irreversibly to M1 muscarinic acetylcholine
CC       receptors. Has no effect on M2 and M4 receptors, but reveal a
CC       slightly weaker effect at M3 receptor.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the snake toxin family. Type A muscarinic
CC       toxin subfamily.
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DR   HSSP; P18328; 1FF4.
DR   InterPro; IPR003571; Snake_toxin.
DR   Pfam; PF00087; Toxin_1; 1.
DR   ProDom; PD000206; Snake_toxin; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
KW   Toxin; Neurotoxin; Postsynaptic neurotoxin;
KW   Acetylcholine receptor inhibitor.
FT   DISULFID      3     24       By similarity.
FT   DISULFID     17     42       By similarity.
FT   DISULFID     46     58       By similarity.
FT   DISULFID     59     64       By similarity.
SQ   SEQUENCE   66 AA;  7518 MW;  EAAC074F4A00DD3E CRC64;
     LTCVTSKSIF GITTENCPDG QNLCFKKWYY IVPRYSDITW GCAATCPKPT NVRETIRCCE
     TDKCNE
//