ID CD4_MACFU Reviewed; 458 AA. AC P79184; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 31-MAY-2011, entry version 66. DE RecName: Full=T-cell surface glycoprotein CD4; DE AltName: Full=T-cell surface antigen T4/Leu-3; DE AltName: CD_antigen=CD4; DE Flags: Precursor; GN Name=CD4; OS Macaca fuscata fuscata (Japanese macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9543; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Hashimoto O., Tatsumi M.; RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Accessory protein for MHC class-II antigen/T-cell CC receptor interaction. May regulate T-cell activation. CC -!- SUBUNIT: Associates with p56-LCK. Interacts with SPG21 (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) CC domains. CC -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) CC domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D63348; BAA09672.1; -; mRNA. DR ProteinModelPortal; P79184; -. DR SMR; P79184; 26-388, 421-458. DR HOVERGEN; HBG005281; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045058; P:T cell selection; ISS:UniProtKB. DR InterPro; IPR000973; Ag_CD4. DR InterPro; IPR015274; CD4-extracel. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR008424; Ig_C2-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR003596; Ig_V-set_subgr. DR InterPro; IPR021963; Tcell_CD4_Cterm. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 4. DR Pfam; PF05790; C2-set; 2. DR Pfam; PF09191; CD4-extracel; 1. DR Pfam; PF12104; Tcell_CD4_Cterm; 1. DR Pfam; PF07686; V-set; 1. DR PRINTS; PR00692; CD4TCANTIGEN. DR SMART; SM00409; IG; 2. DR SMART; SM00406; IGv; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; KW Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Repeat; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 25 By similarity. FT CHAIN 26 458 T-cell surface glycoprotein CD4. FT /FTId=PRO_0000014623. FT TOPO_DOM 26 396 Extracellular (Potential). FT TRANSMEM 397 418 Helical; (Potential). FT TOPO_DOM 419 458 Cytoplasmic (Potential). FT DOMAIN 26 125 Ig-like V-type. FT DOMAIN 126 203 Ig-like C2-type 1. FT DOMAIN 204 317 Ig-like C2-type 2. FT DOMAIN 318 374 Ig-like C2-type 3. FT LIPID 419 419 S-palmitoyl cysteine (By similarity). FT LIPID 422 422 S-palmitoyl cysteine (By similarity). FT CARBOHYD 42 42 N-linked (GlcNAc...) (Potential). FT CARBOHYD 296 296 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 325 325 N-linked (GlcNAc...) (By similarity). FT DISULFID 41 109 By similarity. FT DISULFID 155 184 By similarity. FT DISULFID 328 370 By similarity. SQ SEQUENCE 458 AA; 50828 MW; 76B3E7EF08185535 CRC64; MNRGIPFRHL LLVLQLALLP AVTQGKKVVL GKKGDTVELT CNASQKKNTQ FHWKNSNQIK ILGIQGSFLT KGPSKLSDRA DSRKSLWDQG CFSMIIKNLK IEDSDTYICE VENKKEEVEL LVFGLTANSD THLLEGQSLT LTLESPPGSS PSVKCRSPGG KNIQGGRTIS VPQLERQDSG TWTCTVSQDQ KTVEFKIDIV VLAFQKASST VYKKEGEQVE FSFPLAFTLE KLTGSGELWW QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA LEAKTGKLHQ EVNLVVMRAA QFQENLTCEV WGPTSPKLTL SLKLENKGAT VSKQAKAVWV LNPEAGMWQC LLSDSGQVLL ESNIKVVPTW PTPVQPMALI VLGGVAGLLL FTGLGIFFCV RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR FQKTCSPI //