ID C5AR_GORGO Reviewed; 340 AA. AC P79175; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 29-APR-2008, entry version 48. DE C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen) DE (Fragment). GN Name=C5AR1; Synonyms=C5AR, C5R1; OS Gorilla gorilla gorilla (Lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=96421539; PubMed=8824156; DOI=10.1007/s002510050151; RA Alvarez V., Coto E., Sehen F., Gouzalek-Koces S., Lopez-Larrea C.; RT "Molecular evolution of the N-formyl peptide and C5a receptors in non- RT human primates."; RL Immunogenetics 44:446-452(1996). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- PTM: Sulfation plays a critical role in the association of C5aR CC with C5a, but no significant role in the ability of the receptor CC to transduce a signal and mobilize calcium in response to a small CC peptide agonist (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X97733; CAA66317.1; -; Genomic_DNA. DR InterPro; IPR002234; Anphylx_rcpt. DR InterPro; IPR001274; C5A_anaphtx_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Chemotaxis; G-protein coupled receptor; Membrane; Phosphoprotein; KW Receptor; Sulfation; Transducer; Transmembrane. FT CHAIN <1 >340 C5a anaphylatoxin chemotactic receptor. FT /FTId=PRO_0000069208. FT TOPO_DOM <1 30 Extracellular (Potential). FT TRANSMEM 31 53 1 (Potential). FT TOPO_DOM 54 64 Cytoplasmic (Potential). FT TRANSMEM 65 87 2 (Potential). FT TOPO_DOM 88 103 Extracellular (Potential). FT TRANSMEM 104 125 3 (Potential). FT TOPO_DOM 126 146 Cytoplasmic (Potential). FT TRANSMEM 147 167 4 (Potential). FT TOPO_DOM 168 193 Extracellular (Potential). FT TRANSMEM 194 219 5 (Potential). FT TOPO_DOM 220 235 Cytoplasmic (Potential). FT TRANSMEM 236 258 6 (Potential). FT TOPO_DOM 259 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT TOPO_DOM 297 >340 Cytoplasmic (Potential). FT MOD_RES 4 4 Sulfotyrosine (By similarity). FT MOD_RES 7 7 Sulfotyrosine (By similarity). FT MOD_RES 307 307 Phosphoserine (By similarity). FT MOD_RES 310 310 Phosphoserine (By similarity). FT MOD_RES 320 320 Phosphoserine (By similarity). FT MOD_RES 325 325 Phosphoserine (By similarity). FT MOD_RES 327 327 Phosphoserine (By similarity). FT MOD_RES 331 331 Phosphoserine (By similarity). FT DISULFID 102 181 By similarity. FT NON_TER 1 1 FT NON_TER 340 340 SQ SEQUENCE 340 AA; 38235 MW; 214CFCE78A47B304 CRC64; TPDYGHYDDK DTLDPNTPVD KTSNTLRVPD ILALVIFAVV FLVGVLGNAM VVWVTAFEAK RTINAIWFLN LAVADFLSCL ALPILFTSIV QHHHWPFGGA ACRILPSLIL LNMYASILLL ATISADRFLL VFKPIWCQNF RGAGLAWIAC AVAWGLALLL TIPSFLYRVV REEYFPPKVL CGVDYSHDKR RERAVAIVRL VLGFLWPLLT LTICYTFILL RTWSRRATRS TKTLKVVVAV VASFFIFWLP YQVTGIMMSF LEPSSPTFLL LNKLDSLCVS FAYINCCINP IIYVVAGQGF QGRLRKSLPS LLRNVLTEES VVRESKSFTR STVDTMAQKT //