ID C5AR_GORGO STANDARD; PRT; 340 AA. AC P79175; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 25-OCT-2004 (Rel. 45, Last annotation update) DE C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (Fragment). GN Name=C5R1; Synonyms=C5AR; OS Gorilla gorilla gorilla (Lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96421539; PubMed=8824156; DOI=10.1007/s002510050151; RA Alvarez V., Coto E., Sehen F., Gouzalek-Koces S., Lopez-Larrea C.; RT "Molecular evolution of the N-formyl peptide and C5a receptors in non- RT human primates."; RL Immunogenetics 44:446-452(1996). CC -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide CC anaphylatoxin C5a. This receptor stimulates chemotaxis, granule CC enzyme release and superoxide anion production. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- PTM: Sulfation plays a critical role in the association of C5aR CC with C5a, but no significant role in the ability of the receptor CC to transduce a signal and mobilize calcium in response to a small CC peptide agonist (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X97733; CAA66317.1; -. DR InterPro; IPR002234; Anphylx_receptor. DR InterPro; IPR001274; C5Aantx_receptor. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01104; ANPHYLATOXNR. DR PRINTS; PR00426; C5ANPHYLTXNR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Chemotaxis; G-protein coupled receptor; Glycoprotein; Sulfation; KW Transmembrane. FT NON_TER 1 1 FT DOMAIN <1 30 Extracellular (Potential). FT TRANSMEM 31 53 1 (Potential). FT DOMAIN 54 64 Cytoplasmic (Potential). FT TRANSMEM 65 87 2 (Potential). FT DOMAIN 88 103 Extracellular (Potential). FT TRANSMEM 104 125 3 (Potential). FT DOMAIN 126 146 Cytoplasmic (Potential). FT TRANSMEM 147 167 4 (Potential). FT DOMAIN 168 193 Extracellular (Potential). FT TRANSMEM 194 219 5 (Potential). FT DOMAIN 220 235 Cytoplasmic (Potential). FT TRANSMEM 236 258 6 (Potential). FT DOMAIN 259 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT DOMAIN 297 >340 Cytoplasmic (Potential). FT DISULFID 102 181 By similarity. FT MOD_RES 4 4 Sulfotyrosine (By similarity). FT MOD_RES 7 7 Sulfotyrosine (By similarity). FT NON_TER 340 340 SQ SEQUENCE 340 AA; 38235 MW; 214CFCE78A47B304 CRC64; TPDYGHYDDK DTLDPNTPVD KTSNTLRVPD ILALVIFAVV FLVGVLGNAM VVWVTAFEAK RTINAIWFLN LAVADFLSCL ALPILFTSIV QHHHWPFGGA ACRILPSLIL LNMYASILLL ATISADRFLL VFKPIWCQNF RGAGLAWIAC AVAWGLALLL TIPSFLYRVV REEYFPPKVL CGVDYSHDKR RERAVAIVRL VLGFLWPLLT LTICYTFILL RTWSRRATRS TKTLKVVVAV VASFFIFWLP YQVTGIMMSF LEPSSPTFLL LNKLDSLCVS FAYINCCINP IIYVVAGQGF QGRLRKSLPS LLRNVLTEES VVRESKSFTR STVDTMAQKT //