ID MYO10_BOVIN Reviewed; 2052 AA. AC P79114; DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 28-JUL-2009, entry version 71. DE RecName: Full=Myosin-X; DE AltName: Full=Unconventional myosin-10; GN Name=MYO10; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Aorta; RX MEDLINE=20442246; PubMed=10984435; RA Berg J.S., Derfler B.H., Pennisi C.M., Corey D.P., Cheney R.E.; RT "Myosin-X, a novel myosin with pleckstrin homology domains, associates RT with regions of dynamic actin."; RL J. Cell Sci. 113:3439-3451(2000). CC -!- FUNCTION: Myosins are actin-based motor molecules with ATPase CC activity. Unconventional myosins serve in intracellular movements. CC Their highly divergent tails are presumed to bind to membranous CC compartments, which would be moved relative to actin filaments (By CC similarity). Plays a role in regions of dynamic actin. CC -!- SIMILARITY: Contains 1 FERM domain. CC -!- SIMILARITY: Contains 3 IQ domains. CC -!- SIMILARITY: Contains 1 myosin head-like domain. CC -!- SIMILARITY: Contains 1 MyTH4 domain. CC -!- SIMILARITY: Contains 2 PH domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U55042; AAB39486.1; -; mRNA. DR IPI; IPI00688477; -. DR PIR; T18519; T18519. DR RefSeq; NP_776819.1; -. DR UniGene; Bt.4506; -. DR HSSP; P08799; 1MND. DR Ensembl; ENSBTAT00000026812; ENSBTAP00000026812; ENSBTAG00000020126; Bos taurus. DR GeneID; 281935; -. DR KEGG; bta:281935; -. DR HOVERGEN; P79114; -. DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW. DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003774; F:motor activity; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR014352; FERM/acyl-CoA_bd_prot_3-hlx. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR019747; FERM_CS. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR000048; IQ_CaM_bd_region. DR InterPro; IPR001609; Myosin_head. DR InterPro; IPR000857; MyTH4. DR InterPro; IPR011993; PH_type. DR InterPro; IPR001849; Pleckstrin_homology. DR InterPro; IPR000159; Ras-assoc. DR Gene3D; G3DSA:1.20.80.10; ACBP; 1. DR Gene3D; G3DSA:2.30.29.30; PH_type; 3. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF00612; IQ; 3. DR Pfam; PF00063; Myosin_head; 1. DR Pfam; PF00784; MyTH4; 1. DR Pfam; PF00169; PH; 2. DR Pfam; PF00788; RA; 1. DR PRINTS; PR00193; MYOSINHEAVY. DR ProDom; PD000355; Myosin_head; 1. DR SMART; SM00295; B41; 1. DR SMART; SM00015; IQ; 3. DR SMART; SM00242; MYSc; 1. DR SMART; SM00139; MyTH4; 1. DR SMART; SM00233; PH; 2. DR PROSITE; PS00660; FERM_1; FALSE_NEG. DR PROSITE; PS00661; FERM_2; FALSE_NEG. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS50096; IQ; 2. DR PROSITE; PS51016; MYTH4; 1. DR PROSITE; PS50003; PH_DOMAIN; 2. PE 2: Evidence at transcript level; KW Actin-binding; ATP-binding; Coiled coil; Motor protein; Myosin; KW Nucleotide-binding; Phosphoprotein; Repeat. FT CHAIN 1 2052 Myosin-X. FT /FTId=PRO_0000123472. FT DOMAIN 1 727 Myosin head-like. FT DOMAIN 742 763 IQ 1. FT DOMAIN 764 787 IQ 2. FT DOMAIN 788 817 IQ 3. FT DOMAIN 1206 1304 PH 1. FT DOMAIN 1386 1491 PH 2. FT DOMAIN 1541 1689 MyTH4. FT DOMAIN 1694 2038 FERM. FT COILED 800 941 Potential. FT MOD_RES 961 961 Phosphoserine (By similarity). FT MOD_RES 963 963 Phosphoserine (By similarity). FT MOD_RES 1007 1007 Phosphoserine (By similarity). SQ SEQUENCE 2052 AA; 235839 MW; 43DF13424B4B2D28 CRC64; MDNFFPEGTR VWLRENGQHF PSTVNSCAEG VVVFQTDYGQ VFTYKQSTIT HQKVMPMQPT DEEGVDDMAT LTELHGGAIM HNLYQRYKRN QIYTYIGSII ASVNPYKTIT GLYSRDAVDR YSRCHLGELP PHVFAIANEC YRCLWKRHDN QCVLISGESG AGKTESTKLI LKFLSAISQQ SVDLSSKEKT SSVEQAILES SPIMEAFGNA KTVYNNNSSR FGKFVQLNIG QKGNIQGGRI VDYLLEKNRV VRQNPGERNY HIFYALLAGL GHEEREEFYL SVPENYHYLN QSGCVTDRTI SDQESFREVI MAMEVMQFSK EEVREVLRLL AGILHLGNIE FITAGGAQVS FKTALGRSAE LLGLDPAQLT DALTQRSMFL RGEEILTPLN VQQAADSRDS LAMALYARCF EWVIKKINSR IKGKDDFKSI GILDIFGFEN FEVNHFEQFN INYANEKLQE YFNKHIFSLE QLEYSREGLV WEDIDWIDNG ECLDLIEKKL GLLALINEES HFPQATDSTL LEKLHNQHAN NHFYVKPRVA VNNFGVKHYA GEVQYDVRGI LEKNRDTFRD DLLNLLRESR FDFIYDLFEH VSSRNNQDTL KCGSKHRRPT VSSQFKDSLH SLMATLSASN PFFVRCIKPN MQKMPDQFDQ AVVVNQLRYS GMLETVRIRK AGYAVRRPFQ DFYKRYKVLM RNVALPEDIR GKCTALLQLY DASNSEWQLG KTKVFLRESL EQKLEKRQEE EVTRAAMVIR AHVLGYLARK QYKKVLDCVV IIQKNYRAFL LRRRFLHLKK AAVVFQKQLR GQIARRVYRQ LLAEKRAEEE KRKREEEEKR KREEEERERE RERREAELRA QQEEAARKQR ELEALQQESQ RAAELSRELE KQKENKQVEE ILRLEKEIED LQRMKERQEL SLTEASLQKL QQLRDEELRR LEDEACRAAQ EFLESLNFDE IDECVRNIER SLSVGSGCTG EQGAGAEKPS FNFSQPYPEE EEVDEGFEAD DDAFKDSPNP SEHGHSDQRT SGIRTSDESS EEDPYMNDTV VPTSPSADST VLLAPSEHDS SAGEPTYCLP QTPGALPAPE GDYDYDQDDY EDGAITSGSS VTFSNSCSSQ WSPDYRCSVG TYNSSGAYRF SSEGAQSSFE DSEEDFDSRF DTDDELSYRR DSVYSCVTLP YFHSFLYMKG GLMNSWKRRW CVLKDETFLW FRSKQEALKQ GWLHKKGGGS STLSRRNWKK RWFVLRQAKL MYFENDSEEK LKGTVEVRAA KEIIDNTSKE NGIDIIMADR TFHLIAESPE DASQWFSVLS QVHASTDQEI REMHDEQANP QNAVGTLDVG LIDSVCASDS PDRPNSFVII TANRVLHCNA DTPEEMHHWI TLLQRSKGDT RVEGQEFIVR GWLHKEVKNS PKMSSLKLKK RWFVLTHNSL DYYKSSEKNA LKLGTLVLNS LCSVVPPDEK IFKETGYWNV TVYGRKHCYR LYTKLLNEAT RWSSAIQNVT DTKAPIDTPT QQLIQDIKEN CLNSDVVEQI YKRNPILRHT HHPLHSPLLP LPYGDINLNL LKDKGYTTLQ DEAIKIFNSL QQLESMSDPI PIIQGILQTG HDLRPLRDEL YCQLIKQTNK VPHPGSVGNL CSWQILTCLS CTFLPSRGIL KYLKFHLRRI REQFPGTEME KYALFIYESL KKTKCREFVP SRDEIEALIH RQEMTSTVHC HGGGSCKITV NSHTTAGEVV EKLIRGLAME DSRNMFALFE YNGHVDKAIE SRTIVADVLA KFEKLAATSE VGEQPWKFYF KLYCFLDTDN VPKDSVEFAF MFEQAHEAVI HGHYPAPEEN LQVLAALRLQ YLQGDYAPHA PVPPLEEVYS LQRLKARISQ STKSFTPGER LEKRRTSFLE GTLRRSFRTG SAIRQKAEEE QMVDMWVKEE VCSARASILD KWKKFQGMSQ EQAMAKYMAL IKEWPGYGST LFDVECKEGG FPQDLWLGVS ADAVSVYKRG EGRPLEVFQY EHILSFGAPL ANTYKIVVDE RELLFETSEV VDVAKLMKAY ISMIVKKRYS TSRSVSSQGS SR //