ID   CTG1B_HUMAN             Reviewed;         180 AA.
AC   P78358; A1L417; B7WNL9; Q7LBY4; Q9NY13;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   05-OCT-2010, entry version 88.
DE   RecName: Full=Cancer/testis antigen 1;
DE   AltName: Full=Autoimmunogenic cancer/testis antigen NY-ESO-1;
DE   AltName: Full=Cancer/testis antigen 6.1;
DE            Short=CT6.1;
DE   AltName: Full=L antigen family member 2;
DE            Short=LAGE-2;
GN   Name=CTAG1A; Synonyms=CTAG, CTAG1, ESO1, LAGE2, LAGE2A;
GN   and
GN   Name=CTAG1B; Synonyms=LAGE2B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   MEDLINE=97203161; PubMed=9050879; DOI=10.1073/pnas.94.5.1914;
RA   Chen Y.-T., Scanlan M.J., Sahin U., Tuereci O., Gure A.O., Tsang S.,
RA   Williamson B., Stockert E., Pfreundschuh M., Old L.J.;
RT   "A testicular antigen aberrantly expressed in human cancers detected
RT   by autologous antibody screening.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:1914-1918(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Melanoma;
RX   MEDLINE=98289662; PubMed=9626360;
RX   DOI=10.1002/(SICI)1097-0215(19980610)76:6<903::AID-IJC22>3.0.CO;2-1;
RA   Lethe B.G., Lucas S., Michaux L., De Smet C., Godelaine D.,
RA   Serrano A., De Plaen E., Boon T.;
RT   "LAGE-1, a new gene with tumor specificity.";
RL   Int. J. Cancer 76:903-908(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   MEDLINE=98430682; PubMed=9759882;
RA   Wang R.-F., Johnston S.L., Zeng G., Topalian S.L.,
RA   Schwartzentruber D.J., Rosenberg S.A.;
RT   "A breast and melanoma-shared tumor antigen: T cell responses to
RT   antigenic peptides translated from different open reading frames.";
RL   J. Immunol. 161:3598-3606(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=99454989; PubMed=10523621;
RA   De Smet C., Lurquin C., Lethe B.G., Martelange V., Boon T.;
RT   "DNA methylation is the primary silencing mechanism for a set of germ
RT   line- and tumor-specific genes with a CpG-rich promoter.";
RL   Mol. Cell. Biol. 19:7327-7335(1999).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=21566154; PubMed=11709543; DOI=10.1093/hmg/10.22.2557;
RA   Aradhya S., Bardaro T., Galgoczy P., Yamagata T., Esposito T.,
RA   Patlan H., Ciccodicola A., Kenwrick S., Platzer M., D'Urso M.,
RA   Nelson D.L.;
RT   "Multiple pathogenic and benign genomic rearrangements occur at a 35
RT   kb duplication involving the NEMO and LAGE2 genes.";
RL   Hum. Mol. Genet. 10:2557-2567(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 27-180 (ISOFORM 2).
RA   Lethe B.G.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=12065688;
RA   Satie A.P., Rajpert-De Meyts E., Spagnoli G.C., Henno S., Olivo L.,
RA   Jacobsen G.K., Rioux-Leclercq N., Jegou B., Samson M.;
RT   "The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and
RT   adult testes and in spermatocytic seminomas and testicular carcinoma
RT   in situ.";
RL   Lab. Invest. 82:775-780(2002).
RN   [11]
RP   X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 157-165 IN COMPLEX WITH
RP   T-CELL RECEPTOR.
RX   PubMed=15837811; DOI=10.1084/jem.20042323;
RA   Chen J.-L., Stewart-Jones G., Bossi G., Lissin N.M., Wooldridge L.,
RA   Choi E.M.L., Held G., Dunbar P.R., Esnouf R.M., Sami M., Boulter J.M.,
RA   Rizkallah P., Renner C., Sewell A., van der Merwe P.A., Jakobsen B.K.,
RA   Griffiths G., Jones E.Y., Cerundolo V.;
RT   "Structural and kinetic basis for heightened immunogenicity of T cell
RT   vaccines.";
RL   J. Exp. Med. 201:1243-1255(2005).
CC   -!- INTERACTION:
CC       O60732:MAGEC1; NbExp=2; IntAct=EBI-1188472, EBI-1188463;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P78358-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P78358-2; Sequence=VSP_028548;
CC   -!- TISSUE SPECIFICITY: Expressed in testis and ovary and in a wide
CC       variety of cancers. Detected in uterine myometrium. Expressed from
CC       18 weeks until birth in human fetal testis. In the adult testis,
CC       is strongly expressed in spermatogonia and in primary
CC       spermatocytes, but not in post-meiotic cells or in testicular
CC       somatic cells (at protein level).
CC   -!- SIMILARITY: Belongs to the CTAG family.
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DR   EMBL; U87459; AAB49693.1; -; mRNA.
DR   EMBL; AJ003149; CAA05908.1; -; mRNA.
DR   EMBL; AF038567; AAD05202.1; -; mRNA.
DR   EMBL; AJ275977; CAB76943.1; -; Genomic_DNA.
DR   EMBL; AF277315; AAL27013.1; -; Genomic_DNA.
DR   EMBL; AF277315; AAL27014.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72673.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72674.1; -; Genomic_DNA.
DR   EMBL; BC130362; AAI30363.1; -; mRNA.
DR   EMBL; BC130364; AAI30365.1; -; mRNA.
DR   EMBL; AJ275978; CAB76945.1; -; mRNA.
DR   IPI; IPI00019217; -.
DR   IPI; IPI00386104; -.
DR   RefSeq; NP_001318.1; -.
DR   RefSeq; NP_640343.1; -.
DR   UniGene; Hs.534310; -.
DR   UniGene; Hs.724803; -.
DR   PDB; 2BNQ; X-ray; 1.70 A; C=157-165.
DR   PDB; 2BNR; X-ray; 1.90 A; C=157-165.
DR   PDB; 2F53; X-ray; 2.10 A; C=157-165.
DR   PDB; 2F54; X-ray; 2.70 A; C/H=157-165.
DR   PDB; 2P5E; X-ray; 1.89 A; C=157-165.
DR   PDB; 2P5W; X-ray; 2.20 A; C=157-165.
DR   PDB; 2PYE; X-ray; 2.30 A; C=157-165.
DR   PDB; 3KLA; X-ray; 1.65 A; C/F=157-164.
DR   PDBsum; 2BNQ; -.
DR   PDBsum; 2BNR; -.
DR   PDBsum; 2F53; -.
DR   PDBsum; 2F54; -.
DR   PDBsum; 2P5E; -.
DR   PDBsum; 2P5W; -.
DR   PDBsum; 2PYE; -.
DR   PDBsum; 3KLA; -.
DR   ProteinModelPortal; P78358; -.
DR   IntAct; P78358; 6.
DR   STRING; P78358; -.
DR   PRIDE; P78358; -.
DR   Ensembl; ENST00000328435; ENSP00000332602; ENSG00000184033.
DR   Ensembl; ENST00000333128; ENSP00000332018; ENSG00000183678.
DR   GeneID; 1485; -.
DR   GeneID; 246100; -.
DR   KEGG; hsa:1485; -.
DR   KEGG; hsa:246100; -.
DR   UCSC; uc004fme.1; human.
DR   CTD; 1485; -.
DR   CTD; 246100; -.
DR   GeneCards; GC0XM153845; -.
DR   GeneCards; GC0XP153813; -.
DR   HGNC; HGNC:24198; CTAG1A.
DR   HGNC; HGNC:2491; CTAG1B.
DR   HPA; CAB013061; -.
DR   HPA; CAB015453; -.
DR   MIM; 300156; gene.
DR   MIM; 300657; gene.
DR   PharmGKB; PA26993; -.
DR   eggNOG; prNOG21393; -.
DR   HOVERGEN; HBG051214; -.
DR   InParanoid; P78358; -.
DR   OMA; SRLLEAP; -.
DR   OrthoDB; EOG9DNHRS; -.
DR   NextBio; 6097; -.
DR   CleanEx; HS_CTAG1A; -.
DR   CleanEx; HS_CTAG1B; -.
DR   Genevestigator; P78358; -.
DR   GermOnline; ENSG00000183678; Homo sapiens.
DR   GermOnline; ENSG00000184033; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR015419; EKC/KEOPS_Pcc1.
DR   Pfam; PF09341; Pcc1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Complete proteome; Cytoplasm.
FT   CHAIN         1    180       Cancer/testis antigen 1.
FT                                /FTId=PRO_0000218922.
FT   COMPBIAS      5     82       Gly-rich.
FT   VAR_SEQ     135    180       IRLTAADHRQLQLSISSCLQQLSLLMWITQCFLPVFLAQPP
FT                                SGQRR -> MSVQDQDRDGAWVGGGHSVAGWGLGSAYTPRS
FT                                GC (in isoform 2).
FT                                /FTId=VSP_028548.
SQ   SEQUENCE   180 AA;  17992 MW;  B122C5C2C8BE1569 CRC64;
     MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA
     PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG
     VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR
//