ID SUFC_ECOLI Reviewed; 248 AA. AC P77499; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 25-JAN-2012, entry version 97. DE RecName: Full=Probable ATP-dependent transporter SufC; GN Name=sufC; Synonyms=ynhD; OrderedLocusNames=b1682, JW1672; OS Escherichia coli (strain K12). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX MEDLINE=97251357; PubMed=9097039; DOI=10.1093/dnares/3.6.363; RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., RA Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., RA Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., RA Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., RA Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.; RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome RT corresponding to the 28.0-40.1 min region on the linkage map."; RL DNA Res. 3:363-377(1996). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains RT MG1655 and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [4] RP GENE NAME. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=99255563; PubMed=10322040; RA Patzer S.I., Hantke K.; RT "SufS is a NifS-like protein, and SufD is necessary for stability of RT the 2Fe-2S FhuF protein in Escherichia coli."; RL J. Bacteriol. 181:3307-3309(1999). RN [5] RP FUNCTION, MASS-SPECTROMETRY, SUBUNIT, BIOPHYSICOCHEMICAL PROPERTIES, RP AND SUBCELLULAR LOCATION. RX PubMed=12554644; DOI=10.1093/emboj/cdg061; RA Nachin L., Loiseau L., Expert D., Barras F.; RT "SufC: an unorthodox cytoplasmic ABC/ATPase required for [Fe-S] RT biogenesis under oxidative stress."; RL EMBO J. 22:427-437(2003). RN [6] RP FUNCTION, AND SUBUNIT. RX PubMed=12941942; DOI=10.1074/jbc.M308004200; RA Outten F.W., Wood M.J., Munoz F.M., Storz G.; RT "The SufE protein and the SufBCD complex enhance SufS cysteine RT desulfurase activity as part of a sulfur transfer pathway for Fe-S RT cluster assembly in Escherichia coli."; RL J. Biol. Chem. 278:45713-45719(2003). RN [7] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). RX PubMed=16364320; DOI=10.1016/j.febslet.2005.11.058; RA Kitaoka S., Wada K., Hasegawa Y., Minami Y., Fukuyama K., RA Takahashi Y.; RT "Crystal structure of Escherichia coli SufC, an ABC-type ATPase RT component of the SUF iron-sulfur cluster assembly machinery."; RL FEBS Lett. 580:137-143(2006). CC -!- FUNCTION: Has low ATPase activity. The SufBCD complex acts CC synergistically with SufE to stimulate the cysteine desulfurase CC activity of SufS. The SufBCD complex contributes to the assembly CC or repair of oxygen-labile iron-sulfur clusters under oxidative CC stress. May facilitate iron uptake from extracellular iron CC chelators under iron limitation. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Kinetic parameters: CC KM=0.29 mM for ATP; CC Vmax=4.45 umol/min/mg enzyme; CC -!- SUBUNIT: Part of the SufBCD complex that contains SufB, SufC and CC SufD. Interacts directly with SufB and SufD. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Ycf16 CC family. CC -!- SIMILARITY: Contains 1 ABC transporter domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U00096; AAC74752.1; -; Genomic_DNA. DR EMBL; AP009048; BAA15455.1; -; Genomic_DNA. DR PIR; B64926; B64926. DR RefSeq; NP_416197.1; NC_000913.2. DR PDB; 2D3W; X-ray; 2.50 A; A/B/C/D=1-248. DR PDB; 2ZU0; X-ray; 2.20 A; C/D=1-248. DR PDBsum; 2D3W; -. DR PDBsum; 2ZU0; -. DR ProteinModelPortal; P77499; -. DR SMR; P77499; 1-247. DR DIP; DIP-10939N; -. DR IntAct; P77499; 13. DR 2DBase-Ecoli; P77499; -. DR EnsemblBacteria; EBESCT00000004866; EBESCP00000004866; EBESCG00000003971. DR EnsemblBacteria; EBESCT00000014880; EBESCP00000014171; EBESCG00000013940. DR GeneID; 946128; -. DR GenomeReviews; AP009048_GR; JW1672. DR GenomeReviews; U00096_GR; b1682. DR KEGG; ecj:JW1672; -. DR KEGG; eco:b1682; -. DR PATRIC; 32118670; VBIEscCol129921_1753. DR EchoBASE; EB3722; -. DR EcoGene; EG13964; sufC. DR eggNOG; COG0396; -. DR GeneTree; EBGT00070000031713; -. DR HOGENOM; HBG758042; -. DR OMA; ILRYIKP; -. DR PhylomeDB; P77499; -. DR ProtClustDB; PRK09580; -. DR BioCyc; EcoCyc:G6908-MONOMER; -. DR Genevestigator; P77499; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016887; F:ATPase activity; IEA:InterPro. DR GO; GO:0016226; P:iron-sulfur cluster assembly; IMP:EcoCyc. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR003593; ATPase_AAA+_core. DR InterPro; IPR010230; ATPase_SufC_FeS-cluster_assmbl. DR KO; K09013; -. DR PANTHER; PTHR24220:SF6; PTHR24220:SF6; 1. DR Pfam; PF00005; ABC_tran; 1. DR SMART; SM00382; AAA; 1. DR TIGRFAMs; TIGR01978; SufC; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. PE 1: Evidence at protein level; KW 3D-structure; ATP-binding; Complete proteome; Cytoplasm; KW Nucleotide-binding; Reference proteome; Transport. FT CHAIN 1 248 Probable ATP-dependent transporter SufC. FT /FTId=PRO_0000092980. FT DOMAIN 2 246 ABC transporter. FT NP_BIND 34 41 ATP (Potential). FT STRAND 2 11 FT STRAND 14 24 FT STRAND 29 33 FT HELIX 39 48 FT STRAND 54 62 FT HELIX 67 69 FT HELIX 72 77 FT STRAND 80 82 FT STRAND 88 90 FT HELIX 95 109 FT HELIX 117 130 FT TURN 135 139 FT HELIX 144 162 FT STRAND 165 170 FT HELIX 178 190 FT STRAND 197 201 FT HELIX 208 211 FT STRAND 214 220 FT STRAND 223 228 FT HELIX 232 236 FT TURN 237 240 SQ SEQUENCE 248 AA; 27582 MW; 78FB1108E1850DF9 CRC64; MLSIKDLHVS VEDKAILRGL SLDVHPGEVH AIMGPNGSGK STLSATLAGR EDYEVTGGTV EFKGKDLLAL SPEDRAGEGI FMAFQYPVEI PGVSNQFFLQ TALNAVRSYR GQETLDRFDF QDLMEEKIAL LKMPEDLLTR SVNVGFSGGE KKRNDILQMA VLEPELCILD ESDSGLDIDA LKVVADGVNS LRDGKRSFII VTHYQRILDY IKPDYVHVLY QGRIVKSGDF TLVKQLEEQG YGWLTEQQ //