ID   SUFC_ECOLI              Reviewed;         248 AA.
AC   P77499;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   24-NOV-2009, entry version 79.
DE   RecName: Full=Probable ATP-dependent transporter sufC;
GN   Name=sufC; Synonyms=ynhD; OrderedLocusNames=b1682, JW1672;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   MEDLINE=97251357; PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M.,
RA   Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K.,
RA   Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N.,
RA   Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J.,
RA   Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome
RT   corresponding to the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1474(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   GENE NAME.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=99255563; PubMed=10322040;
RA   Patzer S.I., Hantke K.;
RT   "SufS is a NifS-like protein, and SufD is necessary for stability of
RT   the 2Fe-2S FhuF protein in Escherichia coli.";
RL   J. Bacteriol. 181:3307-3309(1999).
RN   [5]
RP   FUNCTION, MASS-SPECTROMETRY, SUBUNIT, BIOPHYSICOCHEMICAL PROPERTIES,
RP   AND SUBCELLULAR LOCATION.
RX   PubMed=12554644; DOI=10.1093/emboj/cdg061;
RA   Nachin L., Loiseau L., Expert D., Barras F.;
RT   "SufC: an unorthodox cytoplasmic ABC/ATPase required for [Fe-S]
RT   biogenesis under oxidative stress.";
RL   EMBO J. 22:427-437(2003).
RN   [6]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=12941942; DOI=10.1074/jbc.M308004200;
RA   Outten F.W., Wood M.J., Munoz F.M., Storz G.;
RT   "The SufE protein and the SufBCD complex enhance SufS cysteine
RT   desulfurase activity as part of a sulfur transfer pathway for Fe-S
RT   cluster assembly in Escherichia coli.";
RL   J. Biol. Chem. 278:45713-45719(2003).
RN   [7]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RX   PubMed=16364320; DOI=10.1016/j.febslet.2005.11.058;
RA   Kitaoka S., Wada K., Hasegawa Y., Minami Y., Fukuyama K.,
RA   Takahashi Y.;
RT   "Crystal structure of Escherichia coli SufC, an ABC-type ATPase
RT   component of the SUF iron-sulfur cluster assembly machinery.";
RL   FEBS Lett. 580:137-143(2006).
CC   -!- FUNCTION: Has low ATPase activity. The sufBCD complex acts
CC       synergistically with sufE to stimulate the cysteine desulfurase
CC       activity of sufS. The sufBCD complex contributes to the assembly
CC       or repair of oxygen-labile iron-sulfur clusters under oxidative
CC       stress. May facilitate iron uptake from extracellular iron
CC       chelators under iron limitation.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=0.29 mM for ATP;
CC         Vmax=4.45 umol/min/mg enzyme;
CC   -!- SUBUNIT: Part of the sufBCD complex that contains sufB, sufC and
CC       sufD. Interacts directly with sufB and sufD.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Ycf16
CC       family.
CC   -!- SIMILARITY: Contains 1 ABC transporter domain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U00096; AAC74752.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15455.1; -; Genomic_DNA.
DR   PIR; B64926; B64926.
DR   RefSeq; AP_002302.1; -.
DR   RefSeq; NP_416197.1; -.
DR   PDB; 2D3W; X-ray; 2.50 A; A/B/C/D=1-248.
DR   PDB; 2ZU0; X-ray; 2.20 A; C/D=1-248.
DR   PDBsum; 2D3W; -.
DR   PDBsum; 2ZU0; -.
DR   DIP; DIP:10939N; -.
DR   STRING; P77499; -.
DR   2DBase-Ecoli; P77499; -.
DR   GeneID; 946128; -.
DR   GenomeReviews; AP009048_GR; JW1672.
DR   GenomeReviews; U00096_GR; b1682.
DR   KEGG; ecj:JW1672; -.
DR   KEGG; eco:b1682; -.
DR   EchoBASE; EB3722; -.
DR   EcoGene; EG13964; sufC.
DR   HOGENOM; P77499; -.
DR   OMA; ILRYIKP; -.
DR   BioCyc; EcoCyc:G6908-MON; -.
DR   BioCyc; ECOL168927:B1682-MON; -.
DR   Genevestigator; P77499; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR010230; ATPase_SufC_FeS-cluster_assmbl.
DR   PANTHER; PTHR19222:SF6; SufC; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   TIGRFAMs; TIGR01978; sufC; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Complete proteome; Cytoplasm;
KW   Nucleotide-binding; Transport.
FT   CHAIN         1    248       Probable ATP-dependent transporter sufC.
FT                                /FTId=PRO_0000092980.
FT   DOMAIN        2    246       ABC transporter.
FT   NP_BIND      34     41       ATP (Potential).
FT   STRAND        2     11
FT   STRAND       14     24
FT   STRAND       29     33
FT   HELIX        39     48
FT   STRAND       54     62
FT   HELIX        67     69
FT   HELIX        72     77
FT   STRAND       80     82
FT   STRAND       88     90
FT   HELIX        95    109
FT   HELIX       117    130
FT   TURN        135    139
FT   HELIX       144    162
FT   STRAND      165    170
FT   HELIX       178    190
FT   STRAND      197    201
FT   HELIX       208    211
FT   STRAND      214    220
FT   STRAND      223    228
FT   HELIX       232    236
FT   TURN        237    240
SQ   SEQUENCE   248 AA;  27582 MW;  78FB1108E1850DF9 CRC64;
     MLSIKDLHVS VEDKAILRGL SLDVHPGEVH AIMGPNGSGK STLSATLAGR EDYEVTGGTV
     EFKGKDLLAL SPEDRAGEGI FMAFQYPVEI PGVSNQFFLQ TALNAVRSYR GQETLDRFDF
     QDLMEEKIAL LKMPEDLLTR SVNVGFSGGE KKRNDILQMA VLEPELCILD ESDSGLDIDA
     LKVVADGVNS LRDGKRSFII VTHYQRILDY IKPDYVHVLY QGRIVKSGDF TLVKQLEEQG
     YGWLTEQQ
//