ID P74250 PRELIMINARY; PRT; 169 AA. AC P74250; DT 01-FEB-1997 (TrEMBLrel. 02, Created) DT 01-FEB-1997 (TrEMBLrel. 02, Last sequence update) DT 01-MAY-1999 (TrEMBLrel. 10, Last annotation update) DE GLUTATHIONE PEROXIDASE (EC 1.11.1.9). OS Synechocystis sp. (strain PCC 6803). OC Bacteria; Cyanobacteria; Chroococcales; Synechocystis. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=PCC6803; RA TABATA S.; RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC STRAIN=PCC6803; RX MEDLINE; 97061201. RA KANEKO T., SATO S., KOTANI H., TANAKA A., ASAMIZU E., NAKAMURA Y., RA MIYAJIMA N., HIROSAWA M., SUGIURA M., SASAMOTO S., KIMURA T., RA HOSOUCHI T., MATSUNO A., MURAKI A., NAKAZAKI N., NARUO K., OKUMURA S., RA SHIMPO S., TAKEUCHI C., WADA T., WATANABE A., YAMADA M., YASUDA M., RA TABATA S.; RT "Sequence analysis of the genome of the unicellular cyanobacterium RT Synechocystis sp. strain PCC6803. II. Sequence determination of the RT entire genome and assignment of potential protein-coding regions."; RL DNA Res. 3:109-136(1996). CC -!- FUNCTION: PROTECTS CELLS AND ENZYMES FROM OXIDATIVE DAMAGE, BY CC CATALYSING THE REDUCTION OF HYDROGEN PEROXIDE, LIPID PEROXYDES CC AND ORGANIC HYDROPEROXYDE, BY GLUTATHIONE. CC -!- CATALYTIC ACTIVITY: 2 GLUTATHIONE + H(2)O(2) = OXIDIZED CC GLUTATHIONE + 2 H(2)O. CC -!- COFACTOR: SELENOCYSTEINE. CC THE ACTIVE-SITE SELENOCYSTEINE IS ENCODED BY THE OPAL CODON, UGA CC (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE GLUTATHIONE PEROXIDASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D90913; BAA18344.1; -. DR PFAM; PF00255; GSHPx; 1. DR PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1. DR PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1. KW Peroxidase; Oxidoreductase; Selenium; Selenocysteine. FT BINDING 41 41 SELENIUM (BY SIMILARITY). SQ SEQUENCE 169 AA; 18452 MW; 03A20E1C CRC32; MTAQANNTIY GFSANALDGS PVALRDFEGK VLLIVNTASQ CGFTPQYQGL QALYNRFGDR GFTVLGFPCN QFGQQEPGGS GEIKNFCETR YGVTFPLFEK VEVNGPNAHP LFKFLTAASP GMAIPFLGGA EDIKWNFTKF LVDRQGKVVK RYGSIAKPDE IAADIEKLL //