ID CHEY_HELPY Reviewed; 124 AA. AC P71403; O07677; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 10-APR-2019, entry version 118. DE RecName: Full=Chemotaxis protein CheY homolog; GN Name=cheY; OrderedLocusNames=HP_1067; OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter OS pylori). OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=85962; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487; RA Wren B.W.; RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=DSM 4867 / CCUG 17874 / NCTC 11638; RX PubMed=9244252; DOI=10.1128/jb.179.15.4676-4683.1997; RA Beier D., Spohn G., Rappuoli R., Scarlato V.; RT "Identification and characterization of an operon of Helicobacter RT pylori that is involved in motility and stress adaptation."; RL J. Bacteriol. 179:4676-4683(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700392 / 26695; RX PubMed=9252185; DOI=10.1038/41483; RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., RA Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., RA Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., RA Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., RA Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., RA Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., RA Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., RA Smith H.O., Fraser C.M., Venter J.C.; RT "The complete genome sequence of the gastric pathogen Helicobacter RT pylori."; RL Nature 388:539-547(1997). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487; RA Jackson C.J., Pittman M.S., Clayton C.L., McColm A.A., Bagshaw J.A., RA Kelly D.J.; RT "Chemotaxis is essential for virulence in Helicobacter pylori: RT identification of a novel signal transduction protein (CheF) with both RT CheA and CheY domains."; RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the transmission of sensory signals from the CC chemoreceptors to the flagellar motors. CheY seems to regulate the CC clockwise (CW) rotation (By similarity). {ECO:0000250}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250}; CC -!- INTERACTION: CC O25153:HP_0392; NbExp=3; IntAct=EBI-6409045, EBI-6410665; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA57487.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X81897; CAA57487.1; ALT_INIT; Genomic_DNA. DR EMBL; U97567; AAB66375.1; -; Genomic_DNA. DR EMBL; AE000511; AAD08113.1; -; Genomic_DNA. DR EMBL; AF021090; AAD01682.1; -; Genomic_DNA. DR PIR; C64653; C64653. DR RefSeq; NP_207858.1; NC_000915.1. DR RefSeq; WP_000772151.1; NC_018939.1. DR PDB; 3GWG; X-ray; 1.80 A; A=1-124. DR PDB; 3H1E; X-ray; 2.40 A; A=1-124. DR PDB; 3H1F; X-ray; 2.20 A; A=1-124. DR PDB; 3H1G; X-ray; 1.70 A; A=1-124. DR PDBsum; 3GWG; -. DR PDBsum; 3H1E; -. DR PDBsum; 3H1F; -. DR PDBsum; 3H1G; -. DR ProteinModelPortal; P71403; -. DR SMR; P71403; -. DR DIP; DIP-3256N; -. DR IntAct; P71403; 4. DR MINT; P71403; -. DR STRING; 85962.C694_05515; -. DR PaxDb; P71403; -. DR EnsemblBacteria; AAD08113; AAD08113; HP_1067. DR GeneID; 899603; -. DR KEGG; heo:C694_05515; -. DR KEGG; hpy:HP1067; -. DR PATRIC; fig|85962.47.peg.1146; -. DR eggNOG; ENOG4108VYJ; Bacteria. DR eggNOG; COG0784; LUCA. DR KO; K03413; -. DR OMA; AAGAHEY; -. DR BioCyc; HPY:HP1067-MONOMER; -. DR EvolutionaryTrace; P71403; -. DR Proteomes; UP000000429; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0097588; P:archaeal or bacterial-type flagellum-dependent cell motility; IEA:UniProtKB-KW. DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW. DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW. DR CDD; cd00156; REC; 1. DR InterPro; IPR011006; CheY-like_superfamily. DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver. DR Pfam; PF00072; Response_reg; 1. DR SMART; SM00448; REC; 1. DR SUPFAM; SSF52172; SSF52172; 1. DR PROSITE; PS50110; RESPONSE_REGULATORY; 1. PE 1: Evidence at protein level; KW 3D-structure; Chemotaxis; Complete proteome; Cytoplasm; KW Flagellar rotation; Magnesium; Metal-binding; Phosphoprotein; KW Reference proteome; Two-component regulatory system. FT CHAIN 1 124 Chemotaxis protein CheY homolog. FT /FTId=PRO_0000081050. FT DOMAIN 2 120 Response regulatory. FT {ECO:0000255|PROSITE-ProRule:PRU00169}. FT METAL 7 7 Magnesium. {ECO:0000250}. FT METAL 8 8 Magnesium. {ECO:0000250}. FT METAL 53 53 Magnesium. {ECO:0000250}. FT METAL 55 55 Magnesium; via carbonyl oxygen. FT {ECO:0000250}. FT MOD_RES 53 53 4-aspartylphosphate. FT {ECO:0000255|PROSITE-ProRule:PRU00169}. FT VARIANT 122 122 T -> A (in strain: NCTC 11637 and NCTC FT 11638). FT STRAND 3 6 {ECO:0000244|PDB:3H1G}. FT HELIX 10 22 {ECO:0000244|PDB:3H1G}. FT STRAND 28 33 {ECO:0000244|PDB:3H1G}. FT HELIX 34 43 {ECO:0000244|PDB:3H1G}. FT STRAND 49 52 {ECO:0000244|PDB:3H1G}. FT STRAND 57 59 {ECO:0000244|PDB:3H1G}. FT HELIX 61 69 {ECO:0000244|PDB:3H1G}. FT STRAND 74 76 {ECO:0000244|PDB:3H1E}. FT STRAND 79 84 {ECO:0000244|PDB:3H1G}. FT HELIX 88 97 {ECO:0000244|PDB:3H1G}. FT STRAND 101 105 {ECO:0000244|PDB:3H1G}. FT HELIX 109 120 {ECO:0000244|PDB:3H1G}. SQ SEQUENCE 124 AA; 13915 MW; F2B40BC0C04FCBFA CRC64; MKLLVVDDSS TMRRIIKNTL SRLGYEDVLE AEHGVEAWEK LDANADTKVL ITDWNMPEMN GLDLVKKVRS DSRFKEIPII MITTEGGKAE VITALKAGVN NYIVKPFTPQ VLKEKLEVVL GTND //