ID P70408 PRELIMINARY; PRT; 265 AA. AC P70408; DT 01-FEB-1997 (TrEMBLrel. 02, Created) DT 01-FEB-1997 (TrEMBLrel. 02, Last sequence update) DT 01-JUN-2001 (TrEMBLrel. 17, Last annotation update) DE CADHERIN-10 (T2-CADHERIN) (FRAGMENT). GN CDH10. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., AND DEVELOPMENTAL STAGE. RC STRAIN=C57BL/6; TISSUE=TESTIS; RX MEDLINE=97033837; PubMed=8879495; RA Munro S.B., Blaschuk O.W.; RT "A comprehensive survey of the cadherins expressed in the testes of RT fetal, immature, and adult mice utilizing the polymerase chain RT reaction."; RL Biol. Reprod. 55:822-827(1996). RN [2] RP SEQUENCE OF 117-203 FROM N.A. RC STRAIN=CBA/J; TISSUE=THYMOCYTES; RX MEDLINE=96211873; PubMed=8620560; RA Munro S.B., Duclos A.J., Jackson A.R., Baines M.G., Blaschuk O.W.; RT "Characterization of cadherins expressed by murine thymocytes."; RL Cell. Immunol. 169:309-312(1996). CC -!- FUNCTION: CADHERINS ARE CALCIUM DEPENDENT CELL ADHESION PROTEINS. CC THEY PREFERENTIALLY INTERACT WITH THEMSELVES IN A HOMOPHILIC CC MANNER IN CONNECTING CELLS; CADHERINS MAY THUS CONTRIBUTE TO THE CC SORTING OF HETEROGENEOUS CELL TYPES. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN (POTENTIAL). CC -!- DEVELOPMENTAL STAGE: EXPRESSED AT ALL STAGES OF TESTICULAR CC DEVELOPMENT WITH HIGHEST LEVELS FOUND IN FETAL GONAD. CC -!- SIMILARITY: BELONGS TO THE CADHERIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U69137; AAB87708.1; -. DR MGD; MGI:107436; Cdh10. DR InterPro; IPR002126; Cadherin. DR InterPro; IPR000233; Cadherin_C_term. DR Pfam; PF01049; Cadherin_C_term; 1. DR SMART; SM00112; CA; 1. DR PROSITE; PS00232; CADHERIN_1; PARTIAL. DR PROSITE; PS50268; CADHERIN_2; 1. KW Cell adhesion; Glycoprotein; Phosphorylation; Transmembrane; KW Calcium-binding. FT NON_TER 1 1 FT CHAIN <1 265 CADHERIN-10. FT DOMAIN <1 96 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 97 117 POTENTIAL. FT DOMAIN 118 265 CYTOPLASMIC (POTENTIAL). FT DOMAIN <1 90 CADHERIN 5. FT CARBOHYD 18 18 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 265 AA; 29350 MW; 49A15B6C158C5503 CRC64; DDVDRRSFSF SLAAVNPNFT VQDNEDNTAR ILARKNGFNR HEISTYLLPV VISDNDYPIQ SSTGTLTIRV CACDSQGNMQ SCSAEALLLP WPHTGALIAI LLCIIILLVI VVLFAALKEP LILSKEDIRD NIVSYNDEGG GEEDTQAFDI GTLRNPAAIE EKKLRRDIIP ETLFIPRTPT APGNTDVRDF INERLKEHDL DPTAPPYDSL ATYAYEGNDS VAESLSSLES GTTEGDQNYD YLREWGPRFK KLAEMYGGGE SDKDS //