ID TIAR_MOUSE STANDARD; PRT; 392 AA. AC P70318; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE NUCLEOLYSIN TIAR (TIA-1 RELATED PROTEIN). GN TIAL1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=97025375; PubMed=8871565; RA Beck A.R.P., Medley O.G., O'Brien S., Anderson P., Streuli M.; RT "Structure, tissue distribution and genomic organization of the RT murine RRM-type RNA binding proteins TIA-1 and TIAR."; RL Nucleic Acids Res. 24:3829-3836(1996). CC -!- FUNCTION: RNA-BINDING PROTEIN. POSSESSES NUCLEOLYTIC ACTIVITY CC AGAINST CYTOTOXIC LYMPHOCYTE TARGET CELLS. MAY BE INVOLVED IN CC APOPTOSIS (BY SIMILARITY). CC -!- SIMILARITY: CONTAINS 3 RNA RECOGNITION MOTIFS (RRM). CC -!- SIMILARITY: TO NUCLEAR RNA-BINDING PROTEINS. STRONGEST TO TIA-1. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U55861; AAC52870.1; -. DR MGD; MGI:107913; Tial1. DR InterPro; IPR000504; RRM. DR Pfam; PF00076; rrm; 3. DR SMART; SM00360; RRM; 3. DR PROSITE; PS50102; RRM; 3. DR PROSITE; PS00030; RRM_RNP_1; 2. KW RNA-binding; Apoptosis; Repeat. FT DOMAIN 9 102 RNA-BINDING (RRM) 1. FT DOMAIN 114 192 RNA-BINDING (RRM) 2. FT DOMAIN 222 294 RNA-BINDING (RRM) 3. SQ SEQUENCE 392 AA; 43389 MW; 66E6AF14B9EBE77A CRC64; MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEQPDSRRV NSSVGFSVLQ HTSNDPYCFV EFYEHRDAAA ALAAMNGRKI LGKEVKVNWA TTPSSQKKDT SNHFHVFVGD LSPEITTEDI KSAFAPFGKI SDARVVKDMA TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL GGRQIRTNWA TRKPPAPKST QETNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ TFSPFGQIME IRVFPEKGYS FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK NFQQVDYSQW GQWSQVYGNP QQYGQYMANG WQVPPYGVYG QPWNQQGFGV DQSPSAAWMG GFGAQPPQGQ APPPVIPPPN QAGYGMASFP TQ //