ID TIAR_MOUSE STANDARD; PRT; 392 AA. AC P70318; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE) DE NUCLEOLYSIN TIAR (TIA-1 RELATED PROTEIN). GN TIAL1. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC RODENTIA; SCIUROGNATHI; MURIDAE; MURINAE; MUS. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 97025375. RA BECK A.R.P., MEDLEY O.G., O'BRIEN S., ANDERSON P., STREULI M.; RT "Structure, tissue distribution and genomic organization of the RT murine RRM-type RNA binding proteins TIA-1 and TIAR."; RL NUCLEIC ACIDS RES. 24:3829-3836(1996). CC -!- FUNCTION: RNA-BINDING PROTEIN. POSSESSES NUCLEOLYTIC ACTIVITY CC AGAINST CYTOTOXIC LYMPHOCYTE TARGET CELLS. MAY BE INVOLVED IN CC APOPTOSIS (BY SIMILARITY). CC -!- SIMILARITY: CONTAINS 3 RNA RECOGNITION MOTIFS (RNP). CC -!- SIMILARITY: TO NUCLEAR RNA-BINDING PROTEINS. STRONGEST TO TIA-1. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U55861; G1592563; -. DR MGD; MGI:107913; TIAL1. DR PROSITE; PS00030; RNP_1; 2. DR PFAM; PF00076; rrm; 3. KW RNA-BINDING; APOPTOSIS; REPEAT. FT DOMAIN 65 72 RNA-BINDING (RNP1) (BY SIMILARITY). FT DOMAIN 155 162 RNA-BINDING (RNP1) (BY SIMILARITY). FT DOMAIN 257 264 RNA-BINDING (RNP1) (BY SIMILARITY). SQ SEQUENCE 392 AA; 43389 MW; 7DE17820 CRC32; MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEQPDSRRV NSSVGFSVLQ HTSNDPYCFV EFYEHRDAAA ALAAMNGRKI LGKEVKVNWA TTPSSQKKDT SNHFHVFVGD LSPEITTEDI KSAFAPFGKI SDARVVKDMA TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL GGRQIRTNWA TRKPPAPKST QETNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ TFSPFGQIME IRVFPEKGYS FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK NFQQVDYSQW GQWSQVYGNP QQYGQYMANG WQVPPYGVYG QPWNQQGFGV DQSPSAAWMG GFGAQPPQGQ APPPVIPPPN QAGYGMASFP TQ //