ID TIAR_MOUSE STANDARD; PRT; 392 AA. AC P70318; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE NUCLEOLYSIN TIAR (TIA-1 RELATED PROTEIN). GN TIAL1. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RA BECK A.R.P., MEDLEY O.G., O'BRIEN S., ANDERSON P., STREULI M.; RL NUCLEIC ACIDS RES. 24:3829-3836(1996). CC -!- FUNCTION: RNA-BINDING PROTEIN. POSSESSES NUCLEOLYTIC ACTIVITY CC AGAINST CYTOTOXIC LYMPHOCYTE TARGET CELLS. MAY BE INVOLVED IN CC APOPTOSIS (BY SIMILARITY). CC -!- SIMILARITY: CONTAINS 3 RNA RECOGNITION MOTIFS (RNP). CC -!- SIMILARITY: TO NUCLEAR RNA-BINDING PROTEINS. STRONGEST TO TIA-1. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U55861; G1592563; -. DR MGD; MGI:107913; TIAL1. DR PROSITE; PS00030; RNP_1; 2. KW RNA-BINDING; APOPTOSIS; REPEAT. FT DOMAIN 65 72 RNA-BINDING (RNP1) (BY SIMILARITY). FT DOMAIN 155 162 RNA-BINDING (RNP1) (BY SIMILARITY). FT DOMAIN 257 264 RNA-BINDING (RNP1) (BY SIMILARITY). SQ SEQUENCE 392 AA; 43389 MW; 7DE17820 CRC32; MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEQPDSRRV NSSVGFSVLQ HTSNDPYCFV EFYEHRDAAA ALAAMNGRKI LGKEVKVNWA TTPSSQKKDT SNHFHVFVGD LSPEITTEDI KSAFAPFGKI SDARVVKDMA TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL GGRQIRTNWA TRKPPAPKST QETNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ TFSPFGQIME IRVFPEKGYS FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK NFQQVDYSQW GQWSQVYGNP QQYGQYMANG WQVPPYGVYG QPWNQQGFGV DQSPSAAWMG GFGAQPPQGQ APPPVIPPPN QAGYGMASFP TQ //