ID NU6M_BRALA Reviewed; 167 AA. AC P69233; O47432; O79423; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 14-DEC-2022, entry version 55. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 6; GN Name=ND6; Synonyms=NAD6, NADH6; OS Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes; OC Branchiostomidae; Branchiostoma. OX NCBI_TaxID=7740; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=9628930; DOI=10.1093/nar/26.13.3279; RA Spruyt N., Delarbre C., Gachelin G., Laudet V.; RT "Complete sequence of the amphioxus (Branchiostoma lanceolatum) RT mitochondrial genome: relations to vertebrates."; RL Nucleic Acids Res. 26:3279-3285(1998). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone (By CC similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass CC membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16474; CAA76258.1; -; Genomic_DNA. DR PIR; E71391; E71391. DR RefSeq; NP_007548.1; NC_001912.1. DR AlphaFoldDB; P69233; -. DR GeneID; 808211; -. DR CTD; 4541; -. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain; KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1..167 FT /note="NADH-ubiquinone oxidoreductase chain 6" FT /id="PRO_0000118253" FT TRANSMEM 21..41 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 45..65 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 78..98 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 132..152 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 167 AA; 18731 MW; A2CFAD8DC12E68DC CRC64; MQMMLMFLLL LAAIMVIRAT SPYYGALATA WLALLAALLL LDADIIFPAI ILMLIYLGGM LVVFIYSTAY AADLMPLPIN LTMSALMASF GVMLITMISS PSIETLCETK PWLVYDMQPS YMLFDIYQRG SSMFIVAVMI LTALLFSILE VVSHRQTTMK WFIHSTY //