ID NU6M_BRALA Reviewed; 167 AA. AC P69233; O47432; O79423; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 08-MAY-2019, entry version 50. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 6; GN Name=ND6; Synonyms=NAD6, NADH6; OS Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; OC Branchiostoma. OX NCBI_TaxID=7740; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=9628930; DOI=10.1093/nar/26.13.3279; RA Spruyt N., Delarbre C., Gachelin G., Laudet V.; RT "Complete sequence of the amphioxus (Branchiostoma lanceolatum) RT mitochondrial genome: relations to vertebrates."; RL Nucleic Acids Res. 26:3279-3285(1998). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi- CC pass membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16474; CAA76258.1; -; Genomic_DNA. DR PIR; E71391; E71391. DR RefSeq; NP_007548.1; NC_001912.1. DR GeneID; 808211; -. DR CTD; 4541; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain; KW Translocase; Transmembrane; Transmembrane helix; Transport; KW Ubiquinone. FT CHAIN 1 167 NADH-ubiquinone oxidoreductase chain 6. FT /FTId=PRO_0000118253. FT TRANSMEM 21 41 Helical. {ECO:0000255}. FT TRANSMEM 45 65 Helical. {ECO:0000255}. FT TRANSMEM 78 98 Helical. {ECO:0000255}. FT TRANSMEM 132 152 Helical. {ECO:0000255}. SQ SEQUENCE 167 AA; 18731 MW; A2CFAD8DC12E68DC CRC64; MQMMLMFLLL LAAIMVIRAT SPYYGALATA WLALLAALLL LDADIIFPAI ILMLIYLGGM LVVFIYSTAY AADLMPLPIN LTMSALMASF GVMLITMISS PSIETLCETK PWLVYDMQPS YMLFDIYQRG SSMFIVAVMI LTALLFSILE VVSHRQTTMK WFIHSTY //