ID NU6M_BRALA Reviewed; 167 AA. AC P69233; O47432; O79423; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 14-APR-2009, entry version 22. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6; DE EC=1.6.5.3; DE AltName: Full=NADH dehydrogenase subunit 6; GN Name=ND6; Synonyms=NAD6, NADH6; OS Branchiostoma lanceolatum (Common lancelet) (Amphioxus). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; OC Branchiostoma. OX NCBI_TaxID=7740; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=98292550; PubMed=9628930; DOI=10.1093/nar/26.13.3279; RA Spruyt N., Delarbre C., Gachelin G., Laudet V.; RT "Complete sequence of the amphioxus (Branchiostoma lanceolatum) RT mitochondrial genome: relations to vertebrates."; RL Nucleic Acids Res. 26:3279-3285(1998). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol. CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane CC protein (Potential). CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16474; CAA76258.1; -; Genomic_DNA. DR PIR; E71391; E71391. DR RefSeq; NP_007548.1; -. DR GeneID; 808211; -. DR HOVERGEN; P69233; -. DR BRENDA; 1.6.5.3; 282669. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR001457; OxRdtase_q3. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport; Ubiquinone. FT CHAIN 1 167 NADH-ubiquinone oxidoreductase chain 6. FT /FTId=PRO_0000118253. FT TRANSMEM 21 41 Potential. FT TRANSMEM 45 65 Potential. FT TRANSMEM 78 98 Potential. FT TRANSMEM 132 152 Potential. SQ SEQUENCE 167 AA; 18731 MW; A2CFAD8DC12E68DC CRC64; MQMMLMFLLL LAAIMVIRAT SPYYGALATA WLALLAALLL LDADIIFPAI ILMLIYLGGM LVVFIYSTAY AADLMPLPIN LTMSALMASF GVMLITMISS PSIETLCETK PWLVYDMQPS YMLFDIYQRG SSMFIVAVMI LTALLFSILE VVSHRQTTMK WFIHSTY //