ID COX3_BRALA Reviewed; 262 AA. AC P69215; O47425; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 19-FEB-2014, entry version 50. DE RecName: Full=Cytochrome c oxidase subunit 3; DE EC=1.9.3.1; DE AltName: Full=Cytochrome c oxidase polypeptide III; GN Name=COIII; OS Branchiostoma lanceolatum (Common lancelet) (Amphioxus). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; OC Branchiostoma. OX NCBI_TaxID=7740; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=9628930; DOI=10.1093/nar/26.13.3279; RA Spruyt N., Delarbre C., Gachelin G., Laudet V.; RT "Complete sequence of the amphioxus (Branchiostoma lanceolatum) RT mitochondrial genome: relations to vertebrates."; RL Nucleic Acids Res. 26:3279-3285(1998). CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16474; CAA76253.1; -; Genomic_DNA. DR PIR; H71390; H71390. DR RefSeq; NP_007543.1; NC_001912.1. DR ProteinModelPortal; P69215; -. DR SMR; P69215; 4-262. DR GeneID; 808215; -. DR CTD; 4514; -. DR HOVERGEN; HBG016686; -. DR ProtClustDB; MTH00189; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro. DR GO; GO:0034220; P:ion transmembrane transport; IEA:GOC. DR GO; GO:0015992; P:proton transport; IEA:GOC. DR Gene3D; 1.20.120.80; -; 1. DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3. DR InterPro; IPR000298; Cyt_c_oxidase_su3. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR PANTHER; PTHR11403; PTHR11403; 1. DR Pfam; PF00510; COX3; 1. DR SUPFAM; SSF81452; SSF81452; 1. DR PROSITE; PS50253; COX3; 1. PE 3: Inferred from homology; KW Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Transmembrane; Transmembrane helix. FT CHAIN 1 262 Cytochrome c oxidase subunit 3. FT /FTId=PRO_0000183748. FT TRANSMEM 11 31 Helical; (Potential). FT TRANSMEM 32 52 Helical; (Potential). FT TRANSMEM 83 103 Helical; (Potential). FT TRANSMEM 125 147 Helical; (Potential). FT TRANSMEM 160 180 Helical; (Potential). FT TRANSMEM 198 218 Helical; (Potential). FT TRANSMEM 240 260 Helical; (Potential). SQ SEQUENCE 262 AA; 29711 MW; 6D93D8338AC870D8 CRC64; MTGYQPHPWH LVEPSPWPLV GGSAAFTLTV GLVMWFHYNS ISLMILGLVM IVATMIQWWR DVIREATFQG CHTSYVLSGL RRGMVLFIVS EVFFFLAFFW AFFHSSLAPT VELGVTWPPV GVHPLNAFAV PLLNTAVLLS SGVTVTWAHH ALMEGKRTEA IQSLAITVML GLYFTGLQAW EYYEAPFTIA DSVYGSTFFV ATGFHGLHVI IGSTFLMVCL GRQVFYHYTS SHHFGFEAAA WYWHFVDVVW LFLYVCIYWW GS //