ID COX3_BRALA Reviewed; 262 AA. AC P69215; O47425; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 1. DT 13-OCT-2009, entry version 31. DE RecName: Full=Cytochrome c oxidase subunit 3; DE EC=1.9.3.1; DE AltName: Full=Cytochrome c oxidase polypeptide III; GN Name=COIII; OS Branchiostoma lanceolatum (Common lancelet) (Amphioxus). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; OC Branchiostoma. OX NCBI_TaxID=7740; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=98292550; PubMed=9628930; DOI=10.1093/nar/26.13.3279; RA Spruyt N., Delarbre C., Gachelin G., Laudet V.; RT "Complete sequence of the amphioxus (Branchiostoma lanceolatum) RT mitochondrial genome: relations to vertebrates."; RL Nucleic Acids Res. 26:3279-3285(1998). CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16474; CAA76253.1; -; Genomic_DNA. DR PIR; H71390; H71390. DR RefSeq; NP_007543.1; -. DR SMR; P69215; 4-262. DR GeneID; 808215; -. DR CTD; 808215; -. DR HOVERGEN; P69215; -. DR BRENDA; 1.9.3.1; 282669. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0006123; P:mitochondrial electron transport, cytochrom...; IEA:InterPro. DR InterPro; IPR000298; Cyt_c_oxidase_su3. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR Gene3D; G3DSA:1.20.120.80; CytC_oxdse_III_a-bundle; 1. DR PANTHER; PTHR11403; CytC_oxdse_III; 1. DR Pfam; PF00510; COX3; 1. DR ProDom; PD000382; CytC_oxdse_III; 1. DR PROSITE; PS50253; COX3; 1. PE 3: Inferred from homology; KW Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Transmembrane. FT CHAIN 1 262 Cytochrome c oxidase subunit 3. FT /FTId=PRO_0000183748. FT TRANSMEM 11 31 Potential. FT TRANSMEM 32 52 Potential. FT TRANSMEM 83 103 Potential. FT TRANSMEM 125 147 Potential. FT TRANSMEM 160 180 Potential. FT TRANSMEM 198 218 Potential. FT TRANSMEM 240 260 Potential. SQ SEQUENCE 262 AA; 29711 MW; 6D93D8338AC870D8 CRC64; MTGYQPHPWH LVEPSPWPLV GGSAAFTLTV GLVMWFHYNS ISLMILGLVM IVATMIQWWR DVIREATFQG CHTSYVLSGL RRGMVLFIVS EVFFFLAFFW AFFHSSLAPT VELGVTWPPV GVHPLNAFAV PLLNTAVLLS SGVTVTWAHH ALMEGKRTEA IQSLAITVML GLYFTGLQAW EYYEAPFTIA DSVYGSTFFV ATGFHGLHVI IGSTFLMVCL GRQVFYHYTS SHHFGFEAAA WYWHFVDVVW LFLYVCIYWW GS //